Cameroonemide A: a new ceramide from Helichrysum cameroonense

被引：23

作者：

Antoine, Kakam Zanetsie ^{[2
]}

Hussain, Hidayat ^{[1
]}

Dongo, Etienne ^{[2
]}

Kouam, Simeon F. ^{[3
]}

Schulz, Barbara ^{[4
]}

Krohn, Karsten ^{[1
]}

机构：

[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany

[2] Univ Yaounde 1, Fac Sci, Dept Organ Chem, Yaounde, Cameroon

[3] Univ Yaounde 1, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, D-38106 Braunschweig, Germany

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2010年 / 12卷 / 07期

关键词：

Helichrysum cameroonense; Asteraceae; ceramide; antimicrobial activity; TITHONIA-DIVERSIFOLIA; ANTHRAQUINONE; METABOLITES; DITERPENES; LEAVES;

D O I：

10.1080/10286020.2010.485933

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), -sitosterol (4), and -sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.

引用

页码：629 / 633

页数：5

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