Investigation on an application of silver substrates for sensitive surface plasmon resonance imaging detection

被引：40

作者：

Choi, Seung Ho ^{[2
]}

Byun, Kyung Min ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Biomed Engn, Yongin 446701, South Korea

[2] Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 152742, South Korea

来源：

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION | 2010年 / 27卷 / 10期

关键词：

OPTICAL-PROPERTIES; FILMS; BIOSENSORS; SENSORS; ENHANCEMENT;

D O I：

10.1364/JOSAA.27.002229

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A surface plasmon resonance (SPR) imaging biosensor based on silver substrates was investigated to demonstrate that silver could be used as a substrate material for sensitive detection of biomolecular interactions, despite its poor chemical stability. The calculation results showed that oxidation of silver film may lead to a decrease in the sensitivity due to a variation in SPR characteristics such as a broader curve width and shallower minimum reflectance at resonance. The effect of a change in the refractive index of target analytes on the sensitivity was also explored. In particular, it is noteworthy that Ag/Au bimetallic substrates with a thin gold protection layer to prevent oxidation of a silver film can provide a significant amplification of SPR imaging signals in comparison with conventional gold substrates. (C) 2010 Optical Society of America

引用

页码：2229 / 2236

页数：8

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