Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles

被引：97

作者：

Ge, Wenjiao ^{[1
]}

Li, Dong ^{[1
]}

Chen, Meiwan ^{[2
]}

Wang, Xiaohui ^{[1
]}

Liu, Shijie ^{[1
]}

Sun, Runcang ^{[1
,3
]}

机构：

[1] S China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[3] Beijing Forestry Univ, Inst Biomass Chem & Technol, Beijing 100083, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2015年 / 117卷

基金：

中国国家自然科学基金;

关键词：

Chitosan; Self assemble; Nanomicelles; beta-Carotene; Antioxidant activity; IN-VITRO BIOAVAILABILITY; FRAP ASSAY; CHITOSAN; NANOPARTICLES; MICROENCAPSULATION; STABILITY; DELIVERY; CARRIERS; CHITINS; PULP;

D O I：

10.1016/j.carbpol.2014.09.056

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

beta-Carotene (beta-c) is a well-established natural antioxidant agent, but its poor water-solubility, low chemical stability and low bioavailability limit its application in food, pharmaceuticals and cosmetics industries. Thus it is critical to develop an efficient method to improve the water solubility and stability of beta-c. In this research, amphiphilic chitosan-graft-poly (lactide) (CS-g-PLA) copolymer was synthesized via a homogeneous ring-opening polymerization (ROP) in ionic liquid. The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and beta-c loaded micelles (beta-c/m) had low p-c degradation after 15 days. The antioxidant properties of the beta-c/m were investigated by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method, respectively. Significantly improved antioxidant activity was observed for beta-c/m in compare with free p-c. The aqueous dispersion of beta-c/m has potential to be applied in the field of functional food and cosmetics. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：169 / 176

页数：8

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