Fusobacterium nucleatum: a commensal-turned pathogen

被引：553

作者：

Han, Yiping W. ^{[1
,2
,3
]}

机构：

[1] Columbia Univ, Med Ctr, Coll Dent Med, Div Periodont,Sect Oral Diagnost & Sci, New York, NY 10027 USA

[2] Columbia Univ Coll Phys & Surg, Med Ctr, Dept Microbiol & Immunol, New York, NY USA

[3] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Med Ctr, New York, NY 10027 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2015年 / 23卷

基金：

美国国家卫生研究院;

关键词：

PERIODONTAL PATHOGENS; ACUTE APPENDICITIS; COLORECTAL-CANCER; ORAL BACTERIA; INTRAAMNIOTIC INFECTION; AMNIOTIC-FLUID; ROOT CANALS; BONE LOSS; ADHESIN; FADA;

D O I：

10.1016/j.mib.2014.11.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fusobacterium nucleatum is an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases. This article reviews its implication in adverse pregnancy outcomes (chorioamnionitis, preterm birth, stillbirth, neonatal sepsis, preeclampsia), GI disorders (colorectal cancer, inflammatory bowel disease, appendicitis), cardiovascular disease, rheumatoid arthritis, respiratory tract infections, Lemierre's syndrome and Alzheimer's disease. The virulence mechanisms involved in the diseases are discussed, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. The FadA adhesin/invasin conserved in F. nucleatum is a key virulence factor and a potential diagnostic marker for F. nucteatum-associated diseases.

引用

页码：141 / 147

页数：7

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