New guaianolides from Artemisia anomala

被引：11

作者：

Hu, Ze-Hua ^{[1
,2
]}

Zhang, Peng ^{[1
]}

Huang, De-Bin ^{[2
]}

Wu, Ji-Zhou ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Hubei Inst Nationalities, Sch Med, Enshi 445000, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 02期

关键词：

Artemisia anomala; guaianolides; artemanomalides A and B; antiinflammatory activities; SESQUITERPENOIDS;

D O I：

10.1080/10286020.2011.634802

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new guaianolides artemanomalides A and B were isolated from the aerial parts of Artemisia anomala S. Moore. Their structures were characterized as 2-oxo-5a, 10a-dihydroxyguaia- 3-en-1 alpha, 6 beta, 7 alpha, 11 beta II-12, 6-olide ( 1) and 8 alpha-acetoxy-2-oxo-5 alpha, 10 alpha-dihydroxy-guaia-3, 11( 13)-dien-1a, 6b, 7a H-12, 6-olide (2) on the basis of extensive spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities against COX-2 enzyme with IC50 values of 8.8 and 3.6mM.

引用

页码：111 / 114

页数：4

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