Subpicosecond conformational dynamics of small peptides probed by two-dimensional vibrational spectroscopy

被引：178
作者：
Woutersen, S
Mu, YG
Stock, G
Hamm, P
机构：
[1] Max Born Inst Nonlinear Opt & Short Pulse Spect, D-12489 Berlin, Germany
[2] Univ Frankfurt, Inst Phys & Theoret Chem, D-60439 Frankfurt, Germany
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 20期
关键词：
D O I：
10.1073/pnas.201169498
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The observation of subpicosecond fluctuations in the conformation of a small peptide in water is demonstrated. We use an experimental method that is specifically sensitive to conformational dynamics taking place on an ultrafast time scale. Complementary molecular-dynamics simulations confirm that the conformational fluctuations exhibit a subpicosecond component, the time scale and amplitude of which agree well with those derived from the experiment.
引用
收藏
页码：11254 / 11258
页数：5
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