Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

被引：36
|
作者：
Dubee, Vincent [1 ,2 ,3 ,4 ]
Soroka, Daria [1 ,2 ,3 ]
Cortes, Melanie [1 ,2 ,3 ]
Lefebvre, Anne-Laure [1 ,2 ,3 ]
Gutmann, Laurent [1 ,2 ,3 ,5 ]
Hugonnet, Jean-Emmanuel [1 ,2 ,3 ]
Arthur, Michel [1 ,2 ,3 ]
Mainardi, Jean-Luc [1 ,2 ,3 ,5 ]
机构：
[1] INSERM, LRMA, Ctr Rech Cordeliers, Equipe 12,UMR S 1138, Paris, France
[2] Univ Paris 06, Sorbonne Univ, Ctr Rech Cordeliers, UMR S 1138, Paris, France
[3] Univ Paris 05, Ctr Rech Cordeliers, Sorbonne Paris Cite, UMR S 1138, Paris, France
[4] Hop St Antoine, AP HP, Serv Reanimat Med, F-75571 Paris, France
[5] Hop Europeen Georges Pompidou, AP HP, Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 05期
关键词：
MASSILIENSE; CEPHALOSPORIN; INFECTIONS; ACID;
D O I：
10.1128/AAC.05080-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The production of beta-lactamases BlaMab and BlaC contributes to beta-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from >= 256 to 16 to 64 mu g/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.
引用
收藏
页码：2938 / 2941
页数：4
相关论文
共 50 条
  • [41] Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
    Mowbray, Sherry L.
    Kathiravan, Muthu K.
    Pandey, Abhishek A.
    Odell, Luke R.
    MOLECULES, 2014, 19 (09) : 13161 - 13176
  • [42] Prevalence of nontuberculous mycobacteria and high efficacy of D-cycloserine and its synergistic effect with clarithromycin against Mycobacterium fortuitum and Mycobacterium abscessus
    Khosravi, Azar Dokht
    Mirsaeidi, Mehdi
    Farahani, Abbas
    Tabandeh, Mohammad Reza
    Mohajeri, Parviz
    Shoja, Saeed
    Hoseini, Seyedeh Roghayeh
    KhosroShahi, Lar
    INFECTION AND DRUG RESISTANCE, 2018, 11 : 2521 - 2532
  • [43] Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone
    Simithy, Johayra
    Fuanta, Ngolui Rene
    Hobrath, Judith, V
    Kochanowska-Karamyan, Anna
    Hamann, Mark T.
    Goodwin, Douglas C.
    Calderon, Angela, I
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2018, 1866 (5-6): : 731 - 739
  • [44] Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis
    Guardia, Ana
    Baiget, Jessica
    Cacho, Monica
    Perez, Arancha
    Ortega-Guerra, Montserrat
    Nxumalo, Winston
    Khanye, Setshaba D.
    Rullas, Joaquin
    Ortega, Fatima
    Jimenez, Elena
    Perez-Herran, Esther
    Fraile-Gabaldon, Maria Teresa
    Esquivias, Jorge
    Fernandez, Raquel
    Porras-De Francisco, Esther
    Encinas, Lourdes
    Alonso, Marta
    Giordano, Ilaria
    Rivero, Cristina
    Miguel-Siles, Juan
    Osende, Javier G.
    Badiola, Katrina A.
    Rutledge, Peter J.
    Todd, Matthew H.
    Remuinan, Modesto
    Alemparte, Carlos
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (24) : 11327 - 11340
  • [45] Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis
    Islam, Md Imtiazul
    Seo, Hoonhee
    Kim, Sukyung
    Sadu, Venkata S.
    Lee, Kee-In
    Song, Ho-Yeon
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [46] In Vitro Susceptibility of Mycobacterium tuberculosis Isolates to an Oral Carbapenem Alone or in Combination with β-Lactamase Inhibitors
    Horita, Yasuhiro
    Maeda, Shinji
    Kazumi, Yuko
    Doi, Norio
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (11) : 7010 - 7014
  • [47] Inhibition of Mycobacterium abscessus, M. chelonae, and M. fortuitum biofilms by Methylobacterium sp
    Garcia-Coca, Marta
    Rodriguez-Sevilla, Graciela
    Perez-Domingo, Andrea
    Aguilera-Correa, John-Jairo
    Esteban, Jaime
    Munoz-Egea, Maria-Carmen
    JOURNAL OF ANTIBIOTICS, 2020, 73 (01) : 40 - 47
  • [48] Dps protein is related to resistance of Mycobacterium abscessus subsp. massiliense against stressful conditions
    de Alcantara, Nayra Rodrigues
    de Oliveira, Fabio Muniz
    Garcia, Wanius
    Leitao dos Santos, Otavio Augusto
    Junqueira-Kipnis, Ana Paula
    Kipnis, Andre
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 104 (11) : 5065 - 5080
  • [49] In Vivo Assessment of Drug Efficacy against Mycobacterium abscessus Using the Embryonic Zebrafish Test System
    Bernut, Audrey
    Le Moigne, Vincent
    Lesne, Tiffany
    Lutfalla, Georges
    Herrmann, Jean-Louis
    Kremer, Laurent
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) : 4054 - 4063
  • [50] In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice
    Choi, Seoung-ryoung
    Britigan, Bradley E.
    Switzer, Barbara
    Hoke, Traci
    Moran, David
    Narayanasamy, Prabagaran
    MOLECULAR PHARMACEUTICS, 2018, 15 (03) : 1215 - 1225
12345