Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Objective. Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods. Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9 ", "matrix metallopeptidase-9 " and "myocardial infarction ", "acute myocardial infarction ", "AMI ", and "polymorphism ". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0. Results. Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT & TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR=1.49, 95%CI=1.19-1.86, P=0.0004). Such a significance was observed in the overdominant (OR=1.27, 95%CI=1.14-1.41, P < 0.0001) and allele genetic models (OR=1.43, 95%CI=1.17-1.74, P=0.0005) as well. This finding was also valid in the Asian population. Conclusions. Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.