Antiprotozoal alkaloids from Galanthus trojanus

被引：45

作者：

Kaya, Gulen Irem ^{[1
]}

Sarikaya, Buket ^{[1
]}

Onur, Mustafa Ali ^{[1
]}

Somer, Nehir Unver ^{[1
]}

Viladomat, Francesc ^{[2
]}

Codina, Carles ^{[2
]}

Bastida, Jaume ^{[2
]}

Lauinger, Ina L. ^{[3
]}

Kaiser, Marcel ^{[4
]}

Tasdemir, Deniz ^{[3
]}

机构：

[1] Ege Univ, Fac Pharm, Dept Pharmacognosy, TR-35100 Izmir, Turkey

[2] Univ Barcelona, Fac Farm, Dept Prod Nat Biol Vegetal & Edafol, E-08028 Barcelona, Spain

[3] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

[4] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, CH-4002 Basel, Switzerland

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

关键词：

Galanthus trojanus; Amaryllidaceae; Antimalarial activity; Alkaloid N-oxides; HIPPEASTRUM EQUESTRE HERB; AMARYLLIDACEAE ALKALOIDS; N-OXIDES; CONSTITUENTS; LYCORINE; FLOWERS;

D O I：

10.1016/j.phytol.2011.05.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A. P. Davis & N. Ozhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：301 / 305

页数：5

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