Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma

被引：12

作者：

Boot, Arnoud ^{[1
,2
]}

Jiang, Nanhai ^{[1
,2
]}

Rozen, Steven G. ^{[1
,2
,3
,4
]}

机构：

[1] Duke NUS Med Sch, Duke NUS Ctr Computat Biol, 8 Coll Rd, Singapore 1698572, Singapore

[2] Duke NUS Med Sch, Signature Res Programme Canc & Stem Cell Biol, 8 Coll Rd, Singapore 169857, Singapore

[3] SingHealth Duke NUS Inst Precis Med, 5 Hosp Dr, Singapore 169609, Singapore

[4] SingHealth Duke NUS Global Hlth Inst, 8 Coll Rd, Singapore 169857, Singapore

来源：

THERANOSTICS | 2020年 / 10卷 / 12期

基金：

英国医学研究理事会;

关键词：

MUTATIONAL SIGNATURE; NEPHROPATHY; ETIOLOGY; CANCER;

D O I：

10.7150/thno.46489

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A cluster of patients poisoned by herbal medicine in the 1990s revealed that aristolochic acid (AA) causes kidney failure and upper tract urothelial carcinoma (UTUC). Recent research demonstrated that this was not an isolated incident; on the contrary, AA exposure is widespread in East Asia. This editorial highlights research by Lu and colleagues that investigates clinical characteristics of AA and non-AA UTUCs from 90 patients in Beijing based on the AA mutational signature. The study also detected AA mutations in non-tumor tissue of AA exposed patients and showed that AA mutations can be detected in urine, which might form the basis for non-invasive tests for AA exposure.

引用

页码：5578 / 5580

页数：3

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