Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus

被引：10
作者：
Sekiguchi, Kenji [1 ]
Yasui, Naoko [1 ]
Kowa, Hisatomo [1 ]
Kanda, Fumio [1 ]
Toda, Tatsushi [1 ]
机构：
[1] Kobe Univ, Div Neurol, Grad Sch Med, Kobe, Hyogo, Japan
来源：
INTERNAL MEDICINE | 2016年 / 55卷 / 21期
关键词：
human papilloma virus; cervical cancer; acute disseminated encephalomyelitis; vaccination; demyelination; MULTIPLE-SCLEROSIS; DISORDERS; TRIAL;
D O I：
10.2169/internalmedicine.55.5472
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
引用
收藏
页码：3181 / 3184
页数：4
相关论文
共 20 条
  • [1] Pooled analysis of large and long-term safety data from the human papillomavirus-16/18-AS04-adjuvanted vaccine clinical trial programme
    Angelo, Maria-Genalin
    David, Marie-Pierre
    Zima, Julia
    Baril, Laurence
    Dubin, Gary
    Arellano, Felix
    Struyf, Frank
    [J]. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2014, 23 (05) : 466 - 479
  • [2] [Anonymous], 2009, Wkly Epidemiol Rec, V84, P118
  • [3] Demyelinating disease and polyvalent human papilloma virus vaccination
    Chang, Jason
    Campagnolo, Denise
    Vollmer, Timothy L.
    Bomprezzi, Roberto
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (11) : 1296 - 1298
  • [4] Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process
    Confavreux, C
    Vukusic, S
    Adeleine, P
    [J]. BRAIN, 2003, 126 : 770 - 782
  • [5] A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization Against Human Papilloma Virus
    DiMario, Francis J., Jr.
    Hajjar, Mirna
    Ciesielski, Thomas
    [J]. JOURNAL OF CHILD NEUROLOGY, 2010, 25 (03) : 321 - 327
  • [6] Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects
    Grimaldi-Bensouda, L.
    Guillemot, D.
    Godeau, B.
    Benichou, J.
    Lebrun-Frenay, C.
    Papeix, C.
    Labauge, P.
    Berquin, P.
    Penfornis, A.
    Benhamou, P. -Y.
    Nicolino, M.
    Simon, A.
    Viallard, J. -F.
    Costedoat-Chalumeau, N.
    Courcoux, M. -F.
    Pondarre, C.
    Hilliquin, P.
    Chatelus, E.
    Foltz, V.
    Guillaume, S.
    Rossignol, M.
    Abenhaim, L.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2014, 275 (04) : 398 - 408
  • [7] Post-vaccination encephalomyelitis: Literature review and illustrative case
    Huynh, William
    Cordato, Dennis J.
    Kehdi, Elias
    Masters, Lynette T.
    Dedousis, Chris
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2008, 15 (12) : 1315 - 1322
  • [8] The spectrum of post-vaccination inflammatory CNS demyelinating syndromes
    Karussis, Dimitrios
    Petrou, Panayiota
    [J]. AUTOIMMUNITY REVIEWS, 2014, 13 (03) : 215 - 224
  • [9] Consensus definitions proposed for pediatric multiple sclerosis and related disorders
    Krupp, Lauren B.
    Banwell, Brenda
    Tenembaum, Silvia
    [J]. NEUROLOGY, 2007, 68 : S7 - S12
  • [10] Vaccines and the Risk of Multiple Sclerosis and Other Central Nervous System Demyelinating Diseases
    Langer-Gould, Annette
    Qian, Lei
    Tartof, Sara Y.
    Brara, Sonu M.
    Jacobsen, Steve J.
    Beaber, Brandon E.
    Sy, Lina S.
    Chao, Chun
    Hechter, Rulin
    Tseng, Hung Fu
    [J]. JAMA NEUROLOGY, 2014, 71 (12) : 1506 - 1513
12