Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus

被引：10

作者：

Sekiguchi, Kenji ^{[1
]}

Yasui, Naoko ^{[1
]}

Kowa, Hisatomo ^{[1
]}

Kanda, Fumio ^{[1
]}

Toda, Tatsushi ^{[1
]}

机构：

[1] Kobe Univ, Div Neurol, Grad Sch Med, Kobe, Hyogo, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 21期

关键词：

human papilloma virus; cervical cancer; acute disseminated encephalomyelitis; vaccination; demyelination; MULTIPLE-SCLEROSIS; DISORDERS; TRIAL;

D O I：

10.2169/internalmedicine.55.5472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.

引用

页码：3181 / 3184

页数：4

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