Magnetic resonance spectroscopy of serum and acute-phase proteins revisited: a multiparametric statistical analysis of metabolite variations in inflammatory, infectious and miscellaneous diseases

被引：20

作者：

Torri, GM

Torri, J

Gulian, JM

Vion-Dury, J

Viout, P

Cozzone, PJ ^{[1
]}

机构：

[1] Ctr Resonance Magnet Biol & Med, CNRS, UMR 6612, Marseille, France

[2] Fac Med, Chim Biol Lab, F-13005 Marseille, France

来源：

CLINICA CHIMICA ACTA | 1999年 / 279卷 / 1-2期

关键词：

MRS spectroscopy; serum proteins; acute phase proteins; principal component analysis; inflammation;

D O I：

10.1016/S0009-8981(98)00166-1

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Proton MR spectra and biochemical assays have been recorded on the sera of 40 patients and ten controls in order to document the correlation between spectroscopic and biochemical variations in selected pathologies (cancer, inflammatory and infectious diseases, diabetes). N-acetyl proton resonances are essentially generated by the N-acetyl residues of the glucidic moieties borne by the most abundant acute-phase proteins (alpha 1-acid glycoprotein, alpha 1-antitrypsin and haptoglobin). These resonances are not correlated to immunoglobulins A, G and M levels. Principal component analysis shows that variations in spectroscopic and biochemical data are independent markers of the inflammatory status of patients but no additional sensitivity or specificity is obtained when the two sets of data are combined. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：77 / 96

页数：20