Effect of nociceptin on alcohol intake in alcohol preferring rats

被引:118
作者
Ciccocioppo, R
Panocka, I
Polidori, C
Regoli, D
Massi, M
机构
[1] Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, Italy
[2] Polish Acad Sci, Inst Genet & Anim Breeding, Dept Behav Physiol, PL-05551 Mrokow, Poland
[3] Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, Italy
关键词
nociceptin; orphanin FQ; alcohol intake; Marchigian Sardinian alcohol-preferring rat;
D O I
10.1007/s002130050828
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study investigated the effect of nociceptin (NC). the endogenous ligand of the opioid-like orphan receptor ORL1, on ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Acute intracerebroventricular (ICV) injection of 250 or 500 ng/rat of NC, just before access to 10% ethanol (offered 2 h/day), significantly increased ethanol intake. Subchronic (7 days) ICV injection of 500 ng/rat of NC, given just before access to 10% ethanol (for 30 min/day), resulted in a progressive decrease in ethanol consumption. After the end of NC treatment. rats progressively recovered their usual ethanol intake. When NC, 500 or 1000 ng/rat, was tested versus the effect of ethanol in the place conditioning paradigm, NC significantly reduced the increase in time spent in the ethanol-paired compartment after conditioning. This finding suggests that NC reduces the rewarding properties of ethanol in msP rats; thus, they may respond to the acute NC administration by increasing their ethanol intake in an attempt to achieve the usual reinforcing effect of ethanol, whereas subchronic NC treatment may result in extinction of ethanol drinking. The results of the present study suggest that the brain NC mechanisms may represent an interesting target of pharmacological interventions for the treatment of alcoholism.
引用
收藏
页码:220 / 224
页数:5
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