Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome

被引：318

作者：

Bosch, E ^{[1
]}

Valencia, W ^{[1
]}

Escudero, E ^{[1
]}

Crespo, J ^{[1
]}

Simón, C ^{[1
]}

Remohi, J ^{[1
]}

Pellicer, A ^{[1
]}

机构：

[1] Inst Valenciano Infertil, Valencia 46015, Spain

来源：

FERTILITY AND STERILITY | 2003年 / 80卷 / 06期

关键词：

recombinant FSH; premature luteinization; in vitro fertilization; GnRH antagonist;

D O I：

10.1016/j.fertnstert.2003.07.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the prevalence and the effect of premature luteinization in GnRH antagonist IVF-ET cycles. Design: Prospective observational study. Setting: In vitro fertilization-embryo transfer (IVF-ET) program at the Instituto Valenciano de Infertilidad. Patient(s): Eighty-one infertile patients undergoing controlled ovarian hyperstimulation with gonadotropins and GnRH antagonist for IVF-ET. Intervention(s): Gonadotropin-releasing hormone (GnRH) antagonist was administered from stimulation day 6. Serum P, E-2, and LH were determined on the day of hCG administration. Main Outcome Measure(s): Cycles were grouped according to serum P level on the day of hCG administration (< 1.2 ng/mL or greater than or equal to 1.2 ng/mL). Clinical pregnancy and implantation rates were determined. Result(s): The incidence of premature luteinization was 38.3%. Total recombinant FSH dose and stimulation days differed significantly between the groups. Pregnancy rate (25.8% vs. 54.0%) and implantation rate (13.8% vs. 32.0%) were significantly lower in the premature luteinization group. Conclusion(s): Premature luteinization during GnRH antagonist IVF-ET cycles is a frequent event that is associated with lower pregnancy and implantation rates. Progesterone elevations are not related to serum LH levels and may reflect the mature granulosa cell response to high FSH exposure. (C) 2003 by American Society for Reproductive Medicine.

引用

页码：1444 / 1449

页数：6

共 40 条

[21] Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact on pregnancy outcome [J].