Catalytic antibodies for organic synthesis

被引：0

作者：

Reymond, JL ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

BIOCATALYSIS - FROM DISCOVERY TO APPLICATION | 1999年 / 200卷

关键词：

catalytic antibodies; biotransformations; enantioselective reactions; transition state analogs; high throughput screening;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monoclonal antibodies with strong binding affinities tailored to any molecular target can be produced from immunized mice using hybridoma technology. Due to their directable binding specificities and ease of preparation, monoclonal antibodies are used in the daily practice of biological research as well as in many diagnostic applications. Since 1986 monoclonal antibodies with catalytic properties have been prepared by immunizing mice with stable transition state analogs of chemical reactions, thereby providing a versatile source of novel biocatalysts. This review discusses catalytic antibodies with respect to organic synthetic reactions.

引用

页码：59 / 93

页数：35

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