Coregulator-dependent facilitation of chromatin occupancy by GATA-1

被引：128
作者：
Pal, S
Cantor, AB
Johnson, KD
Moran, TB
Boyer, ME
Orkin, SH
Bresnick, EH
机构：
[1] Univ Wisconsin, Sch Med, Dept Pharmacol, Mol & Cellular Pharmacol Program, Madison, WI 53706 USA
[2] Harvard Univ, Childrens Hosp, Sch Med, Div Hematol Oncol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 04期
关键词：
D O I：
10.1073/pnas.0307612100
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Coregulator recruitment by DNA-bound factors results in chromatin modification and protein-protein interactions, which regulate transcription. However, the mechanism by which the Friend of GATA (FOG) coregulator mediates GATA factor-dependent transcription is unknown. We showed previously that GATA-1 replaces GATA-2 at an upstream region of the GATA-2 locus, and that this GATA switch represses GATA-2. Genetic complementation analysis in FOG-1-null hematopoietic precursors revealed that FOG-1 is not required for establishment or maintenance of the active GATA-2 domain, but is critical for the GATA switch. Analysis of GATA factor binding to additional loci also revealed FOG-1-dependent GATA switches. Thus, FOG-1 facilitates chromatin occupancy by GATA-1 at sites bound by GATA-2. We propose that FOG-1 is a prototype of a new class of coregulators termed chromatin occupancy facilitators, Which confer coregulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo.
引用
收藏
页码：980 / 985
页数：6
相关论文
共 46 条
[1]   Deletion of the mouse α-globin regulatory element (HS-26) has an unexpectedly mild phenotype [J].
Anguita, E ;
Sharpe, JA ;
Sloane-Stanley, JA ;
Tufarelli, C ;
Higgs, DR ;
Wood, WG .
BLOOD, 2002, 100 (10) :3450-3456
[2]   X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation [J].
Bellefroid, EJ ;
Bourguignon, C ;
Hollemann, T ;
Ma, QF ;
Anderson, DJ ;
Kintner, C ;
Pieler, T .
CELL, 1996, 87 (07) :1191-1202
[3]   CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation [J].
Blobel, GA ;
Nakajima, T ;
Eckner, R ;
Montminy, M ;
Orkin, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2061-2066
[4]   Perturbation of nucleosome structure by the erythroid transcription factor GATA-1 [J].
Boyes, J ;
Omichinski, J ;
Clark, D ;
Pikaart, M ;
Felsenfeld, G .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 279 (03) :529-544
[5]  
BRESNICK EH, 2003, NATURE ENCY HUMAN GE, V3, P260
[6]   Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation [J].
Brownell, JE ;
Zhou, JX ;
Ranalli, T ;
Kobayashi, R ;
Edmondson, DG ;
Roth, SY ;
Allis, CD .
CELL, 1996, 84 (06) :843-851
[7]   Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation [J].
Cantor, AB ;
Katz, SG ;
Orkin, SH .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) :4268-4279
[8]   GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis [J].
Chang, AN ;
Cantor, AB ;
Fujiwara, Y ;
Lodish, MB ;
Droho, S ;
Crispino, JD ;
Orkin, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9237-9242
[9]   Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4 [J].
Cirillo, LA ;
Lin, FR ;
Cuesta, I ;
Friedman, D ;
Jarnik, M ;
Zaret, KS .
MOLECULAR CELL, 2002, 9 (02) :279-289
[10]   Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation:: The GATA-1:FOG complex [J].
Crispino, JD ;
Lodish, MB ;
MacKay, JP ;
Orkin, SH .
MOLECULAR CELL, 1999, 3 (02) :219-228
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