Human exposure to acrolein: Time -dependence and individual variation in eye irritation

被引：15

作者：

Claeson, Anna-Sara ^{[1
]}

Lind, Nina ^{[2
]}

机构：

[1] Umea Univ, Dept Psychol, Umea, Sweden

[2] Swedish Univ Agr Sci, Dept Econ, Uppsala, Sweden

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 45卷

基金：

瑞典研究理事会;

关键词：

Human exposure; Eye irritation; Sensory irritation detection threshold; Time dependence; Acrolein; TRPA1; CHEMICAL-SENSITIVITY SCALE; EVENT-RELATED POTENTIALS; SENSORY IRRITATION; TEMPORAL INTEGRATION; CHEMOSENSORY PERCEPTION; COVALENT MODIFICATION; NASAL LATERALIZATION; GENDER-DIFFERENCES; ORGANIC-COMPOUNDS; PERCEIVED STRESS;

D O I：

10.1016/j.etap.2016.05.011

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of the study was to examine the time dependence on sensory irritation detection following exposure to threshold levels of acrolein, in humans. The exposures occurred in an exposure chamber and the subjects were breathing fresh air through a mask that covered the nose and mouth. All participants participated in four exposure conditions, of which three consisted of a mixture of acrolein and heptane and one of only heptane. Exposure to acrolein at a concentration half of the TLV-C lead to sensory irritation. The perceived sensory irritation resulted in both increased detectability and sensory irritation after about 6.8 min of exposure in 58% of the participants. The study confirm the previously suggested LOAEL of about 0.34mg/m(3) for eye irritation due to acrolein exposure. The sensory irritation was still significant 10 min after exposure. These results have implications for risk assessment and limit setting in occupational hygiene. (c) 2016 Elsevier B.V. All rights reserved.

引用

页码：20 / 27

页数：8

共 69 条

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