Deep-Red and Near-Infrared Xanthene Dyes for Rapid Live Cell Imaging

被引：44

作者：

Niu, Guangle ^{[1
,2
,3
]}

Liu, Weimin ^{[1
,2
]}

Zhou, Bingjiang ^{[1
,2
,4
]}

Xiao, Hongyan ^{[1
,2
]}

Zhang, Hongyan ^{[1
,2
]}

Wu, Jiasheng ^{[1
,2
]}

Ge, Jiechao ^{[1
,2
]}

Wang, Pengfei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, CityU CAS Joint Lab Funct Mat & Devices, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 17期

基金：

中国国家自然科学基金;

关键词：

INTRAMOLECULAR CHARGE-TRANSFER; FLUORESCENT DYES; PHOTOPHYSICAL PROPERTIES; RHODAMINE DYES; FAR-RED; PROBE; RNA; EMISSION; WAVELENGTH; DESIGN;

D O I：

10.1021/acs.joc.6b00981

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, two xanthene dyes (H-hNR and TF-hNR) have been synthesized by a convenient and efficient method. These two dyes exhibited deep-red and near-infrared emissions, high fluorescence quantum yields, and good photostability. Their structure-optical properties were investigated by X-ray crystal structure analysis and density functional theory calculations. Live cell imaging data revealed that H-hNR and TF-hNR could rapidly stain both A549 and HeLa cells with low concentrations. The excellent photo-physical and imaging properties render them as promising candidates for use in live cell imaging.

引用

页码：7393 / 7399

页数：7

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