A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease

被引：38

作者：

Arlotti, Mattia ^{[1
]}

Colombo, Matteo ^{[1
]}

Bonfanti, Andrea ^{[1
,2
]}

Mandat, Tomasz ^{[3
]}

Lanotte, Michele Maria ^{[4
,5
]}

Pirola, Elena ^{[6
]}

Borellini, Linda ^{[6
]}

Rampini, Paolo ^{[6
]}

Eleopra, Roberto ^{[7
]}

Rinaldo, Sara ^{[7
]}

Romito, Luigi ^{[7
]}

Janssen, Marcus L. F. ^{[8
,9
]}

Priori, Alberto ^{[10
]}

Marceglia, Sara ^{[11
]}

机构：

[1] Newronika SpA, Milan, Italy

[2] Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy

[3] Narodowy Inst Onkol Marii Sklodowskiej Curie, Warsaw, Poland

[4] Univ Torino, Dept Neurosci, Turin, Italy

[5] Molinette Mauriziano Hosp, AOU Citta Salute & Sci, Turin, Italy

[6] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[7] Fdn IRCCS Ist Neurol C Besta, Dept Clin Neurosci, Movement Disorders Unit, Milan, Italy

[8] Maastricht Univ, Med Ctr, Dept Neurol & Clin Neurophysiol, Maastricht, Netherlands

[9] Maastricht Univ, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, Maastricht, Netherlands

[10] Univ Milan, Aldo Ravelli Res Ctr Neurotechnol & Expt Neurothe, Dept Hlth Sci, Milan, Italy

[11] Univ Trieste, Dipartimento Ingn & Architettura, Trieste, Italy

来源：

FRONTIERS IN NEUROSCIENCE | 2021年 / 15卷

关键词：

deep brain stimulation; neuromodulation; closed-loop; local field potential (LFP); Parkinson's disease; neural interface; implantable device; DEEP BRAIN-STIMULATION; LOCAL-FIELD POTENTIALS; ARTIFACT; DEVICE; PERSPECTIVES; OSCILLATIONS; SUPPRESSION; LEVODOPA; DBS;

D O I：

10.3389/fnins.2021.763235

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBS(R) System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson's disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

引用

页数：12

共 61 条

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