Role of donor HLA class I mismatch, KIR-ligand mismatch and HLA:KIR pairings in hematological malignancy relapse after unrelated hematopoietic stem cell transplantation

被引：11

作者：

Graczyk-Pol, Elzbieta ^{[1
]}

Rogatko-Koros, Marta ^{[1
]}

Nestorowicz, Klaudia ^{[1
]}

Gwozdowicz, Slawomir ^{[1
]}

Mika-Witkowska, Renata ^{[1
]}

Pawliczak, Daria ^{[1
]}

Zubala, Marta ^{[1
]}

Szlendak, Urszula ^{[1
]}

Witkowska, Agnieszka ^{[1
]}

Tomaszewska, Agnieszka ^{[2
]}

Nasilowska-Adamska, Barbara ^{[2
]}

Szczepinski, Andrzej ^{[2
]}

Wojcik, Michal ^{[2
]}

Halaburda, Kazimierz ^{[2
]}

Nowak, Jacek ^{[1
]}

机构：

[1] Inst Hematol & Transfus Med, Dept Immunogenet, 14 Indira Gandhi St, PL-02776 Warsaw, Poland

[2] Inst Hematol & Transfus Med, Dept Hematopoiet Stem Cell Transplantat, Warsaw, Poland

来源：

HLA | 2018年 / 92卷

关键词：

hematopoietic stem cell transplantation; HLA-KIR cognate pairs; HLA mismatch; KIR-ligand mismatch; relapse incidence; NATURAL-KILLER-CELLS; MISSING SELF; SURVIVAL; INCOMPATIBILITY; ALLOREACTIVITY; EDUCATION; LEUKEMIA; RISK;

D O I：

10.1111/tan.13386

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA are functional in cancer immunosurveillance in adaptive and innate immunity pathways. In unrelated hematopoietic stem cell transplantation (HSCT) in 688 patients with hematological malignancies we compared antitumor efficacy of transplant in three models including the level of: (a) donor-recipient HLA class I mismatch, (b) KIR-ligand mismatch, (c) post-transplant cognate HLA:KIR pairing. The effects were directly compared in multivariate models with backward elimination including all three effects in initial model. In final multivariate model HLA mismatch and KIR-ligand mismatch levels were eliminated and HLA:KIR-dependent NK cell licensing effect remained independent prognostic factor for DFS, relapse/progression incidence, and overall survival (OS). These results suggested that NK cell licensing via cognate HLA:KIR pairs is primarily functional in cancer immunosurveillance in HSCT.

引用

页码：42 / 46

页数：5

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