Cancer microenvronment and inflammation: role of hyaluronan

被引：96
作者：
Nikitovic, Dragana [1 ]
Tzardi, Maria [1 ]
Berdiaki, Aikaterini [1 ]
Tsatsakis, Aristidis [1 ]
Tzanakakis, George N. [1 ]
机构：
[1] Univ Crete, Sch Med, Iraklion 71003, Greece
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
cancer microenvironment; inflammation; hyaluronan; RHAMM; CD44; INTERCELLULAR-ADHESION MOLECULE-1; MEDIATED MOTILITY RHAMM; EXTRACELLULAR-MATRIX; NITRIC-OXIDE; PEPTIDE VACCINATION; DENDRITIC CELLS; CD44; EXPRESSION; GROWTH; RECEPTORS;
D O I：
10.3389/fimmu.2015.00169
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of inflammation in the development of cancer was described as early as the nineteenth century. Abundant evidence supports the preposition that various cancers are triggered by infection and chronic inflammatory disease whereas, evading immune destruction has been proposed as one of the new "hallmarks of cancer." Changes of the tumor microenvironment have been closely correlated to cancer-mediated inflammation. Hyaluronan (HA), an important extracellular matrices component, has become recognized as an active participant in inflammatory, angiogenic, fibrotic, and cancer promoting processes. This review discusses how HA and specific HA-binding proteins participate in and regulate cancer-related inflammatory processes.
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页数：7
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