Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

被引：55

作者：

Mueller, Stephan ^{[1
,2
]}

Preische, Oliver ^{[2
,3
]}

Sohrabi, Hamid R. ^{[4
,5
]}

Graber, Susanne ^{[1
,2
,3
]}

Jucker, Mathias ^{[3
,6
]}

Ringman, John M. ^{[7
]}

Martins, Ralph N. ^{[4
,5
]}

McDade, Eric ^{[8
]}

Schofield, Peter R. ^{[9
,10
]}

Ghetti, Bernardino ^{[11
]}

Rossor, Martin ^{[12
]}

Fox, Nick N. ^{[12
]}

Graff-Radford, Neill R. ^{[13
,14
]}

Levin, Johannes ^{[15
,16
]}

Danek, Adrian ^{[15
,16
]}

Voeglein, Jonathan ^{[15
,16
]}

Salloway, Stephen ^{[17
]}

Xiong, Chengjie ^{[18
]}

Benzinger, Tammie ^{[19
]}

Buckles, Virginia ^{[19
]}

Masters, Colin L. ^{[20
]}

Sperling, Reisa ^{[21
]}

Bateman, Randall J. ^{[19
]}

Morris, John C. ^{[19
]}

Laske, Christoph ^{[1
,2
,3
]}

机构：

[1] Univ Tubingen, Sect Dementia Res, Dept Cellular Neurol, Hertie Inst Clin Brain Res, Tubingen, Germany

[2] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[4] Edith Cowan Univ, Sch Med & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia

[5] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia

[6] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Cellular Neurol, Tubingen, Germany

[7] USC, Keck Sch Med, Memory & Aging Ctr, Los Angeles, CA USA

[8] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[9] Neurosci Res Australia, Sydney, NSW, Australia

[10] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia

[11] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA

[12] UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, Queen Sq, London, England

[13] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[14] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[15] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[16] Ludwig Maximilians Univ Munchen, Dept Neurol, Munich, Germany

[17] Brown Univ, Warren Alpert Med Sch, Dept Neurol, Providence, RI 02912 USA

[18] Washington Univ, Sch Med, Div Biostat, Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA

[19] Washington Univ, Sch Med, Dept Neurol, Knight Alzheimers Dis Res Ctr, St Louis, MO 63110 USA

[20] Univ Melbourne, Florey Inst, Parkville, Vic, Australia

[21] Harvard Med Sch, Massachusetts Gen Hosp, Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment,Dept Neurol, Boston, MA USA

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 11期

关键词：

Physical activity; Dominantly inherited Alzheimer's disease; Cognitive function; Functional status; Cerebrospinal fluid biomarkers; Mutation carrier; OLDER-ADULTS; AMYLOID LOAD; MOUSE MODEL; EXERCISE; DEMENTIA; RISK; DECLINE; IMPAIRMENT; BETA; PERFORMANCE;

D O I：

10.1016/j.jalz.2018.06.3059

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1427 / 1437

页数：11

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