Indole alkaloids from the leaves of Philippine Alstonia scholaris

被引：84

作者：

Macabeo, APG

Krohn, K

Gehle, D

Read, RW

Brophy, JJ

Cordell, GA

Franzblau, SG

Aguinaldo, AM

机构：

[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany

[2] Univ Santo Tomas, Res Ctr Nat Sci, Phyochem Lab, Manila 1008, Philippines

[3] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia

[4] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[5] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 10期

关键词：

Alstonia scholaris; Apocynaceae; manilamine; N-4-methyl angustilobine B; mass spectrometry; NMR spectroscopy; monoterpene indole; alkaloid biogenesis;

D O I：

10.1016/j.phytochem.2005.02.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first seco-uleine alkaloids, manilamine (1) (18-hydroxy-19,20-dehydro-7,21-seco-uleine) and N-4-methyl angustilobine B (2), were isolated from the (pH 5) alkaloid extract of Philippine Alstonia scholaris leaves together with the known indole alkaloids 19,20(E)-vallesamine (3), angustilobine B N-4-oxide (4), 20(S)-tubotaiwine (5), and 6,7-seco-angustilobine B (6). The structure of the alkaloids was established from MS and NMR experiments. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1158 / 1162

页数：5

共 19 条

[1]

ABE F, 1989, CHEM PHARM BULL, V37, P887, DOI 10.1248/cpb.37.887

[2]

[Anonymous], 1981, INTRO ALKALOIDS BIOG

[3] ALKALOIDS FROM ALSTONIA-CONGENSIS [J].