Disease or not, aging is easily treatable

被引:38
作者
Blagosklonny, Mikhail V. [1 ]
机构
[1] Roswell Pk Canc Inst, Cell Stress Biol, Buffalo, NY 14263 USA
来源
AGING-US | 2018年 / 10卷 / 11期
关键词
gerossuppresants; senolytics; longevity; lifespan; EXTENDS LIFE-SPAN; DIABETES PREVENTION PROGRAM; BASAL-STATE HYPERINSULINEMIA; HEALTHY NORMOGLYCEMIC ADULTS; ALL-CAUSE MORTALITY; CALORIE RESTRICTION; CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; CANCER PREVENTION; BREAST-CANCER;
D O I
10.18632/aging.101647
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Is aging a disease? It does not matter because aging is already treated using a combination of several clinicallyavailable drugs, including rapamycin. Whether aging is a disease depends on arbitrary definitions of both disease and aging. For treatment purposes, aging is a deadly disease (or more generally, pre-disease), despite being a normal continuation of normal organismal growth. It must and, importantly, can be successfully treated, thereby delaying classic age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegeneration.
引用
收藏
页码:3067 / 3078
页数:12
相关论文
共 147 条
  • [1] Metformin slows down aging and extends life span of female SHR mice
    Anisimov, Vladimir N.
    Berstein, Lev M.
    Egormin, Peter A.
    Piskunova, Tatiana S.
    Popovich, Irina G.
    Zabezhinski, Mark A.
    Tyndyk, Margarita L.
    Yurova, Maria V.
    Kovalenko, Irina G.
    Poroshina, Tatiana E.
    Semenchenko, Anna V.
    [J]. CELL CYCLE, 2008, 7 (17) : 2769 - 2773
  • [2] Metformin for cancer and aging prevention: is it a time to make the long story short?
    Anisimov, Vladimir N.
    [J]. ONCOTARGET, 2015, 6 (37) : 39398 - 39407
  • [3] Metformin Do we finally have an anti-aging drug?
    Anisimov, Vladimir N.
    [J]. CELL CYCLE, 2013, 12 (22) : 3483 - 3489
  • [4] Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    Anisimov, Vladimir N.
    Zabezhinski, Mark A.
    Popovich, Irina G.
    Piskunova, Tatiana S.
    Semenchenko, Anna V.
    Tyndyk, Margarita L.
    Yurova, Maria N.
    Rosenfeld, Svetlana V.
    Blagosklonny, Mikhail V.
    [J]. CELL CYCLE, 2011, 10 (24) : 4230 - 4236
  • [5] If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
    Anisimov, Vladimir N.
    Berstein, Lev M.
    Popovich, Irina G.
    Zabezhinski, Mark A.
    Egormin, Peter A.
    Piskunova, Tatiana S.
    Semenchenko, Anna V.
    Tyndyk, Margarita L.
    Yurova, Maria N.
    Kovalenko, Irina G.
    Poroshina, Tatiana E.
    [J]. AGING-US, 2011, 3 (02): : 148 - 157
  • [6] Metformin for aging and cancer prevention
    Anisimov, Vladimir N.
    [J]. AGING-US, 2010, 2 (11): : 760 - 774
  • [7] Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
    Anisimov, Vladimir N.
    Zabezhinski, Mark A.
    Popovich, Irina G.
    Piskunova, Tatiana S.
    Semenchenko, Anna V.
    Tyndyk, Margarita L.
    Yurova, Maria N.
    Antoch, Marina P.
    Blagosklonny, Mikhail V.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) : 2092 - 2097
  • [8] Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
    Aroda, Vanita R.
    Knowler, William C.
    Crandall, Jill P.
    Perreault, Leigh
    Edelstein, Sharon L.
    Jeffries, Susan L.
    Molitch, Mark E.
    Pi-Sunyer, Xavier
    Darwin, Christine
    Heckman-Stoddard, Brandy M.
    Temprosa, Marinella
    Kahn, Steven E.
    Nathan, David M.
    Grp, Diabet Prevention Program Res
    [J]. DIABETOLOGIA, 2017, 60 (09) : 1601 - 1611
  • [9] Beta Blockers and Breast Cancer Mortality: A Population-Based Study
    Barron, Thomas I.
    Connolly, Roisin M.
    Sharp, Linda
    Bennett, Kathleen
    Visvanathan, Kala
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (19) : 2635 - 2644
  • [10] Protective effect of long-term angiotensin II inhibition
    Basso, Nidia
    Cini, Rosa
    Pietrelli, Adriana
    Ferder, Leon
    Terragno, Norberto A.
    Inserra, Felipe
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (03): : H1351 - H1358