Metal-assisted red light-induced efficient DNA cleavage by dipyridoquinoxaline-copper(II) complex

被引:81
作者
Dhar, S [1 ]
Senapati, D [1 ]
Reddy, PAN [1 ]
Das, PK [1 ]
Chakravarty, AR [1 ]
机构
[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India
关键词
D O I
10.1039/b308344f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Complete cleavage of double stranded pUC19 DNA by the complex [Cu(dpq)(2)(H2O)](ClO4)(2) (dpq, dipyridoquinoxaline) has been observed on irradiation at 694 nm from a pulsed ruby laser, assisted by the metal d-band transition as well as the quinoxaline triplet states in the absence of any external additives.
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收藏
页码:2452 / 2453
页数:2
相关论文
共 19 条
[1]  
Ackroyd R, 2001, PHOTOCHEM PHOTOBIOL, V74, P656, DOI 10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO
[2]  
2
[3]  
BATLLE AMD, 1993, J PHOTOCH PHOTOBIO B, V20, P5
[4]   Efficient copper (II)-mediated nuclease activity of ortho-quinacridines [J].
Baudoin, O ;
Teulade-Fichou, MP ;
Vigneron, JP ;
Lehn, JM .
CHEMICAL COMMUNICATIONS, 1998, (21) :2349-2350
[5]   Photosensitized generation of hydroxyl radical by eight new sulfur and selenium analogs of psoralen [J].
Collet, M ;
Hoebeke, M ;
Piette, J ;
Jakobs, A ;
Lindqvist, L ;
VandeVorst, A .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1996, 35 (03) :221-231
[6]   Photosensitized singlet oxygen and its applications [J].
DeRosa, MC ;
Crutchley, RJ .
COORDINATION CHEMISTRY REVIEWS, 2002, 233 :351-371
[7]   Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaidimine [J].
Dhar, S ;
Chakravarty, AR .
INORGANIC CHEMISTRY, 2003, 42 (08) :2483-2485
[8]   Transition metal Kinamycin model as a DNA photocleaver for hypoxic environments: bis(9-diazo-4,5-diazafluorene)copper(II) nitrate [J].
Eppley, HJ ;
Sato, SM ;
Ellington, AD ;
Zaleski, JM .
CHEMICAL COMMUNICATIONS, 1999, (23) :2405-2406
[9]  
FIEL RJ, 1981, CANCER RES, V41, P3543
[10]  
Henderson BW, 2000, CANCER RES, V60, P525