CRYSTAL STRUCTURES OF [N′-(2-OXIDOBENZYLIDENE)-N-(PROP-2-EN-1-YL)- CARBAMOHYDRAZONOTHIOATO(2-)](1,10-PHENANTHROLINE)COPPER AND [N′-(2-OXIDOBENZYLIDENE)-N-(PROP-2-EN-1-YL)-CARBAMOHYDRAZONOTHIOATO(2-)](2,2′- BIPYRIDINE)COPPER HEMIHYDRATES

被引:1
作者
Chumakov, Yu. M. [1 ]
Graur, V. O. [2 ]
Ulchina, Ya. I. [2 ]
Smaglii, V. A. [3 ]
Gulea, A. P. [2 ]
Garbuz, O. S. [2 ,4 ]
Tsapkov, V. I. [2 ]
机构
[1] Inst Appl Phys, Kishinev, Moldova
[2] Moldova State Univ, Kishinev, Moldova
[3] Inst Chem, Kishinev, Moldova
[4] Inst Zool, Kishinev, Moldova
关键词
Cu(II) complexes; salicylaldehyde; 4-allylthiosemicarbazone; mixed-ligand amine-containing complexes; antimicrobial; antifungal; and antioxidant activities; IN-VITRO ANTILEUKEMIA; COORDINATION-COMPOUNDS; LIGAND SYNTHESIS; COMPLEXES; THIOSEMICARBAZONES; SALICYLALDEHYDE; ANTIBACTERIAL; DERIVATIVES; ANTIFUNGAL; CU(II);
D O I
10.1134/S0022476622060075
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The crystal structures and biological properties of [N'-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](1,10-phenanthroline)copper hemihydrate [Cu(1,10-Phen)(L)]center dot 0.5H(2)O (I) and [N'-(2-oxidobenzylidene)-N-(prop-2-en-1-yl)-carbamohydrazonothioato(2-)](2,2'-bipyridine)copper hemihydrate [Cu(2,2 '-BPy)(L)]center dot 0.5H(2)O (II), where H2L is 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide, are determined. The asymmetric unit of the unit cell in the crystal structures of I and II contains a copper complex with bidentate amine and a ligand coordinated by the azomethine nitrogen atom, the deprotonated phenolic oxygen atom, and the sulfur atom in the thiol form. The coordination polyhedron of the copper atom in compounds I and II is a distorted tetragonal pyramid. Obtained coordination compounds I and II exhibit antimicrobial and antifungal activities and have minimum inhibitory concentration and bactericidal concentration values in a range of 1.5-500 mu g/mL. The study of the antioxidant activity shows that compounds I and II are less active than uncoordinated thiosemicarbazone H2L, but more active than trolox used in medical practice.
引用
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页码:905 / 913
页数:9
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