Highly diastereoselective formation of ruthenium complexes for efficient catalytic asymmetric transfer hydrogenation

被引：97
作者：
Baratta, Walter
Chelucci, Giorgio
Herdtweck, Eberhardt
Magnolia, Santo
Siega, Katia
Rigo, Pierluigi
机构：
[1] Univ Udine, Dipartimento Sci Tecnol Chim, I-33100 Udine, Italy
[2] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 40期
关键词：
asymmetric catalysis; chiral resolution; hydrogen transfer; phosphane ligands; ruthenium;
D O I：
10.1002/anie.200702278
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Jumping Josiphos! Ruthenium cis-dichloro complexes with matched chiral diphosphane and aminopyridine ligands (see structure) are easily obtained by a one-pot reaction of [RuCl 2(PPh3)3] with a Josiphos diphosphane and racemic 1-substituted 1-(pyridin-2-yl)methanamine ligands. These complexes are highly active catalysts for the transfer hydrogenation of ketones, affording turnover frequencies of up to 70000 h-1 at 60°C and ee values up to 99%. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：7651 / 7654
页数：4
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