Aptamers Against COVID-19: An Untested Opportunity

被引：1

作者：

Haberland, Annekathrin ^{[1
]}

Mueller, Johannes ^{[2
]}

机构：

[1] Berlin Cures GmbH, Robert Rossle Str 10, D-13125 Berlin, Germany

[2] Berlin Cures GmbH, Knesebeckstr 59-61, D-10719 Berlin, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 13期

关键词：

Aptamer; BC; 007; COVID-19; long-COVID-19; multiple modes-of-action; SARS-CoV-2; SARS CORONAVIRUS; DNA APTAMERS; PROTEIN; COMPLEX; DOMAIN; AS1411;

D O I：

10.2174/1389557522666220112094951

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Given the lack of success in the development of effective drugs to treat COVID-19, which show "game-changing" potential, it is necessary to explore drugs with different modes of action. Single mode-of-action drugs have not been succeeded in curing COVID-19, which is a highly complex disease. This is the case for direct antivirals and anti-inflammatory drugs, both of which treat different phases of the disease. Aptamers are molecules that deliver different modes of action, allowing their effects to be bundled, which, when combined, support their therapeutic efficacy. In this minireview, we summarise the current activities in the development of aptamers for the treatment of COVID-19 and long-COVID. A special emphasis is placed on the capability of their multiple modes of action, which is a promising approach for treating complex diseases such as COVID-19.

引用

页码：1708 / 1715

页数：8

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