Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution

被引：35

作者：

Glenfield, Cian ^{[1
]}

Innan, Hideki ^{[1
]}

机构：

[1] Grad Univ Adv Studies, SOKENDAI, Dept Evolutionary Studies Biosyst, Hayama, Kanagawa 2400193, Japan

来源：

GENES | 2021年 / 12卷 / 09期

关键词：

tumour evolution; gene duplication; gene amplification; gene fusion; cancer genome; genome rearrangement; DIHYDROFOLATE-REDUCTASE GENES; CHRONIC MYELOGENOUS LEUKEMIA; TRANSCRIPTION FACTOR GENES; ACUTE MYELOID-LEUKEMIA; ABL TYROSINE KINASE; C-MYC-ONCOGENE; PROSTATE-CANCER; RECURRENT FUSION; CIRCULAR DNA; COPY-NUMBER;

D O I：

10.3390/genes12091376

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for initiation of tumour formation, and some even have the capability of transforming normal cells, highlighting the importance of understanding the events that result in their formation. The mechanisms that drive gene duplication and fusion are unregulated in cancer and they facilitate rapid evolution by selective forces akin to Darwinian survival of the fittest on a cellular level. In this review, we examine current knowledge of the landscape and prevalence of gene duplication and gene fusion in human cancers.

引用

页数：20

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