Chemistry - Metal-based therapeutics

被引:201
作者
Hambley, Trevor W. [1 ]
机构
[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia
关键词
D O I
10.1126/science.1150504
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Metals and metal complexes can make multiple contributions to drug development, but are not receiving the attention they merit.
引用
收藏
页码:1392 / 1393
页数:2
相关论文
共 17 条
[1]   Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance [J].
Ang, WH ;
Khalaila, I ;
Allardyce, CS ;
Juillerat-Jeanneret, L ;
Dyson, PJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (05) :1382-1383
[2]   Targeting the mitochondrial cell death pathway with gold compounds [J].
Barnard, Peter J. ;
Berners-Price, Susan J. .
COORDINATION CHEMISTRY REVIEWS, 2007, 251 (13-14) :1889-1902
[3]   Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes [J].
Barnes, KR ;
Kutikov, A ;
Lippard, SJ .
CHEMISTRY & BIOLOGY, 2004, 11 (04) :557-564
[4]  
Davies NM, 2004, J PHARM PHARM SCI, V7, P332
[5]  
*DURH U, 2007, DALT DISC, V10
[6]   Studies of a cobalt(III) complex of the MMP inhibitor marimastat: A potential hypoxia-activated prodrug [J].
Failes, Timothy W. ;
Cullinane, Carleen ;
Diakos, Connie I. ;
Yamamoto, Natsuho ;
Lyons, J. Guy ;
Hambley, Trevor W. .
CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (10) :2974-2982
[7]  
Gielen M., 2005, METALLOTHERAPEUTIC D
[8]   Pharma challenged [J].
Grimley, Joanne .
CHEMICAL & ENGINEERING NEWS, 2006, 84 (49) :17-+
[9]  
HAMBLEY TW, 2007, J CHEM SOC DA, P4929
[10]   Stressed out hearts [J].
Hutchinson, Ezzie .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) :720-720