机构:
Wellcome Trust Med Res Council Cambridge Stem Cel, Tennis Court Rd, Cambridge CB2 1QR, England
Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Hills Rd, Cambridge CB2 0XZ, EnglandWellcome Trust Med Res Council Cambridge Stem Cel, Tennis Court Rd, Cambridge CB2 1QR, England
Alcolea, Maria P.
[1
,2
]
机构:
[1] Wellcome Trust Med Res Council Cambridge Stem Cel, Tennis Court Rd, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Hills Rd, Cambridge CB2 0XZ, England
来源:
STEM CELL MICROENVIRONMENTS AND BEYOND
|
2017年
/
1041卷
Oesophageal cancer remains one of the least explored malignancies. However, in recent years its increasing incidence and poor prognosis have stimulated interest from the cancer community to understand the pathways to the initiation and progression of the disease. Critical understanding of the molecular processes controlling changes in stem cell fate and the cross-talk with their adjacent stromal neighbours will provide essential knowledge on the mechanisms that go awry in oesophageal carcinogenesis. Advances in lineage tracing techniques have represented a powerful tool to start understanding changes in oesophageal cell behaviour in response to mutations and mutagens that favour tumour development. Environmental cues constitute an important factor in the aetiology of oesophageal cancer. The oesophageal epithelium is a tissue exposed to harsh conditions that not only damage the DNA of epithelial cells but also result in an active stromal reaction, promoting tumour progression. Ultimately, cancer represents a complex interplay between malignant cells and their microenvironment. Indeed, increasing evidence suggests that the accumulation of somatic mutations is not the sole cause of cancer. Instead, non-cell autonomous components, coming from the stroma, can significantly contribute from the earliest stages of tumour formation. The realisation that stromal cells play an important role in cancer has transformed this cellular compartment into an attractive and emerging field of research. It is becoming increasingly clear that the tumour microenvironment provides unique opportunities to identify early diagnostic and prognostic markers, as well as potential therapeutic strategies that may synergise with those targeting tumour cells. This chapter compiles recent observations on oesophageal epithelial stem cell biology, and how environmental and micro-environmental changes may lead to oesophageal disease and cancer.
机构:
Greater Baltimore Med Ctr, Dept Internal Med, Baltimore, MD USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Latt, Nyan L.
Shin, Eun J.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Shin, Eun J.
Wang, Li-Dong
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou, Henan, Peoples R ChinaJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Wang, Li-Dong
Wang, Liang
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Wang, Liang
Yang, Wancai
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Univ Illinois, Dept Pathol, Chicago, IL USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Yang, Wancai
Velculescu, Victor E.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Velculescu, Victor E.
Vogelstein, Bert
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Vogelstein, Bert
Papadopoulos, Nickolas
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Papadopoulos, Nickolas
Kinzler, Kenneth W.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Kinzler, Kenneth W.
Meltzer, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Alcolea, Maria P.
Greulich, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Greulich, Philip
Wabik, Agnieszka
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Wabik, Agnieszka
Frede, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Frede, Julia
Simons, Benjamin D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 1QN, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Simons, Benjamin D.
Jones, Philip H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
Arwert, Esther N.
Hoste, Esther
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
Hoste, Esther
Watt, Fiona M.
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
机构:
Greater Baltimore Med Ctr, Dept Internal Med, Baltimore, MD USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Latt, Nyan L.
Shin, Eun J.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Shin, Eun J.
Wang, Li-Dong
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou, Henan, Peoples R ChinaJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Wang, Li-Dong
Wang, Liang
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Wang, Liang
Yang, Wancai
论文数: 0引用数: 0
h-index: 0
机构:
Xinxiang Med Univ, Dept Pathol, Zhengzhou, Henan, Peoples R China
Univ Illinois, Dept Pathol, Chicago, IL USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Yang, Wancai
Velculescu, Victor E.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Velculescu, Victor E.
Vogelstein, Bert
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Vogelstein, Bert
Papadopoulos, Nickolas
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Papadopoulos, Nickolas
Kinzler, Kenneth W.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
Kinzler, Kenneth W.
Meltzer, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21287 USAJohns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Alcolea, Maria P.
Greulich, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Greulich, Philip
Wabik, Agnieszka
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Wabik, Agnieszka
Frede, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Frede, Julia
Simons, Benjamin D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 1QN, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
Simons, Benjamin D.
Jones, Philip H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, EnglandUniv Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge CB2 0XZ, England
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
Arwert, Esther N.
Hoste, Esther
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England
Hoste, Esther
Watt, Fiona M.
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, EnglandLi Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England