Synthesis of oxo analogs of Lamotrigine and related compounds

被引：9

作者：

Hlavác, J ^{[1
]}

Buchtík, R ^{[1
]}

Slouka, J ^{[1
]}

Hradil, P ^{[1
]}

Wiedermannova, I ^{[1
]}

机构：

[1] Palacky Univ, Dept Organ Chem, Tr Svobody 8, CZ-77146 Olomouc, Czech Republic

来源：

ARKIVOC | 2003年

关键词：

Lamotrigine analogs; 6-azauracils; isatin semicarbazone recyclization;

D O I：

10.3998/ark.5550190.0004.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lamotrigine oxoanalog 8 was prepared using 5-(2-amino-5,6-dichlorophenyl)-6-azauracil 3 as starting compound. A series of 5-( 2,3-dichlorophenyl)-6-azauracil derivatives 9 - 12 with additional substituents in the benzene ring were synthesized as well. The conversion of hydrazone 13 to derivative 14 containing two 6- azauracil rings is also described.

引用

页码：22 / 28

页数：7

共 11 条

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