Solid-phase synthesis of peptide aminoalkylamides using an allyl linker

被引：38

作者：

Kaljuste, K ^{[1
]}

Unden, A ^{[1
]}

机构：

[1] STOCKHOLM UNIV,DEPT NEUROCHEM & NEUROTOXICOL,S-10691 STOCKHOLM,SWEDEN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 17期

关键词：

D O I：

10.1016/0040-4039(96)00461-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of an allylic linker is presented to which primary and secondary amino groups can be anchored on solid phase. By acylating MBHA resin with allyl linker HO-CH2-CH=CH-CH2-O-CH2-COOH followed by treatment with 4-nitrophenyl chloroformate a mixed carbonate linker is obtained to which amino groups can be attached, The allyl carbamate linkage is stable to both bases and anhydrous acids and can be cleaved by palladium-catalysed allyl transfer under mild reaction conditions. (C) 1996 Elsevier Science Ltd

引用

页码：3031 / 3034

页数：4

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