Congenital fibrinogen disorders with repeated thrombosis

被引：5

作者：

Zhang, Xiuli ^{[1
]}

Zhang, Chuang ^{[1
]}

Wang, Baoheng ^{[1
]}

Chen, Ningheng ^{[1
]}

Sun, Gaihe ^{[1
]}

Guo, Xueli ^{[1
]}

机构：

[1] First Affiliated Hosp Zhengzhou Univ, Div Blood Vessel Surg, . 1 Jianshe E Rd, Zhengzhou, Peoples R China

来源：

JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2020年 / 49卷 / 02期

关键词：

Congenital fibrinogen disorders; Congenital dysfibrinogenemia; Thrombosis; Fibrinogen; GAMMA-CHAIN; DYSFIBRINOGENEMIA; MUTATIONS; DELETION; HYPODYSFIBRINOGENAEMIA; AFIBRINOGENEMIA; IDENTIFICATION; BINDING;

D O I：

10.1007/s11239-019-01958-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congenital dysfibrinogenemia is characterized with undetectable or low fibrinogen level by Clauss assay complicated by bleeding and/or thrombosis. These may lead to a diagnostic problem to some clinicians unfamiliar with this disease. We reported a case of congenital dysfibrinogenemia manifested as hemorrhage, repeated thrombosis, low fibrinogen levels through Clauss assay and but normal levels of fibrinogen through PT-derived tests. In conclusion, to patients with thrombosis complicated by decreased fibrinogen level, clinicians and laboratory physicians should be alert to the possibility of congenital dysfibrinogenemia.

引用

页码：312 / 315

页数：4

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