The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers

被引：17
作者：
Liang, Yabing [1 ]
Yang, Ling [1 ]
Xie, Jingwu [2 ]
机构：
[1] Inner Mongolia Med Univ, Clin Med Res Ctr, Inner Mongolia Key Lab Med Cell Biol, Affiliated Hosp, Hohhot 010050, Peoples R China
[2] Indiana Univ Sch Med, Wells Ctr Pediat Res, Dept Pediat, Indianapolis, IN 46202 USA
来源：
CELLS | 2021年 / 10卷 / 08期
基金：
中国国家自然科学基金;
关键词：
the hedgehog pathway; chemotherapy; resistance; gastric cancer; colorectal cancer; pancreatic cancer; SONIC HEDGEHOG; GASTRIC-CANCER; STEM-CELLS; SIGNALING PATHWAY; DRUG-RESISTANCE; MOUSE MODEL; INHIBITION; PROLIFERATION; GEMCITABINE; PROMOTES;
D O I：
10.3390/cells10082030
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway's roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
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页数：10
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