共 31 条
Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines
被引:32
作者:

Cekay, Michael John
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Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany

Roesler, Stefanie
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Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany

Frank, Tanja
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Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany

Knuth, Anne-Kathrin
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Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany

Eckhardt, Ines
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h-index: 0
机构:
Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany
German Canc Consortium DKFK, Partner Site Frankfurt, Frankfurt, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany

Fulda, Simone
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h-index: 0
机构:
Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany
German Canc Consortium DKFK, Partner Site Frankfurt, Frankfurt, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany
机构:
[1] Goethe Univ, Inst Expt Canc Res Pediat, Komturstr 3a, D-60528 Frankfurt, Germany
[2] German Canc Consortium DKFK, Partner Site Frankfurt, Frankfurt, Germany
[3] German Canc Res Ctr, Heidelberg, Germany
来源:
关键词:
Cell death;
Necroptosis;
Smac;
Interferon;
Cancer;
BYPASSES APOPTOSIS RESISTANCE;
CARCINOMA-CELLS;
ALPHA;
ACTIVATION;
DEATH;
NECROSIS;
D O I:
10.1016/j.canlet.2017.09.002
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)gamma to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. This synergism is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i.e. BV6, Birinapant), pointing to a broader relevance. Importantly, individual genetic knockdown of key components of necroptosis signaling, i.e. receptor-interacting protein (RIP) 1, RIP3 or mixed lineage kinase domain-like pseudokinase (MLKL), significantly protects from BV6/IFN gamma-induced cell death. Similarly, pharmacological inhibitors of RIP1 (necrostatin-1(Nec-1)), RIP3 (GSK'872) or MLKL (necrosulfonamide (NSA)) significantly reduce BV6/IFN gamma-stimulated cell death. Of note, IFN-regulatory factor (IRF)1 is required for BV6/IFN gamma-mediated necroptosis, as IRF1 silencing provides protection from cell death. By comparison, antibodies blocking tumor necrosis factor (TNF)alpha, TNF-related apoptosis-inducing ligand (TRAIL) or CD95 ligand fail to inhibit BV6/IFN gamma-induced cell death, pointing to a mechanism independently of death receptor ligands. This is the first report showing that Smac mimetics synergize with IFN gamma to trigger necroptosis in apoptosis-resistant cancer cells with important implications for Smac mimetic based strategies for the treatment of cancer. (C) 2017 Elsevier B.V. All rights reserved.
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页码:228 / 237
页数:10
相关论文
共 31 条
[1]
Synergistic interaction of Smac mimetic and IFNα to trigger apoptosis in acute myeloid leukemia cells
[J].
Bake, Vanessa
;
Roesler, Stefanie
;
Eckhardt, Ines
;
Belz, Katharina
;
Fulda, Simone
.
CANCER LETTERS,
2014, 355 (02)
:224-231

Bake, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Roesler, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Eckhardt, Ines
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Belz, Katharina
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Fulda, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
[2]
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly
[J].
Belz, Katharina
;
Schoeneberger, Hannah
;
Wehner, Sibylle
;
Weigert, Andreas
;
Boenig, Halvard
;
Klingebiel, Thomas
;
Fichtner, Iduna
;
Fulda, Simone
.
BLOOD,
2014, 124 (02)
:240-250

Belz, Katharina
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Schoeneberger, Hannah
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Wehner, Sibylle
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Childrens Hosp, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

论文数: 引用数:
h-index:
机构:

Boenig, Halvard
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Transfus Med & Immunohematol, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Klingebiel, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Childrens Hosp, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Fichtner, Iduna
论文数: 0 引用数: 0
h-index: 0
机构:
Max Delbruck Ctr Mol Med, Berlin, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Fulda, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
[3]
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
[J].
Beug, Shawn T.
;
Beauregard, Caroline E.
;
Healy, Cristin
;
Sanda, Tarun
;
St-Jean, Martine
;
Chabot, Janelle
;
Walker, Danielle E.
;
Mohan, Aditya
;
Earl, Nathalie
;
Lun, Xueqing
;
Senger, Donna L.
;
Robbins, Stephen M.
;
Staeheli, Peter
;
Forsyth, Peter A.
;
Alain, Tommy
;
LaCasse, Eric C.
;
Korneluk, Robert G.
.
NATURE COMMUNICATIONS,
2017, 8

Beug, Shawn T.
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Beauregard, Caroline E.
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Healy, Cristin
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Sanda, Tarun
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

St-Jean, Martine
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Chabot, Janelle
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Walker, Danielle E.
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Mohan, Aditya
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Earl, Nathalie
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Lun, Xueqing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Arnie Charbonneau Canc Inst, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Senger, Donna L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Arnie Charbonneau Canc Inst, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Robbins, Stephen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Arnie Charbonneau Canc Inst, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Staeheli, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Freiburg, Inst Virol, D-79104 Freiburg, Germany Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Forsyth, Peter A.
论文数: 0 引用数: 0
h-index: 0
机构:
H Lee Moffitt Canc Ctr & Res Inst, 12902 Magnolia Dr, Tampa, FL 33612 USA Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

论文数: 引用数:
h-index:
机构:

LaCasse, Eric C.
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Korneluk, Robert G.
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Res Inst, Apoptosis Res Ctr, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
[4]
Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
[J].
Chou, Ting-Chao
.
CANCER RESEARCH,
2010, 70 (02)
:440-446

Chou, Ting-Chao
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, Preclin Pharmacol Core Lab, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, Preclin Pharmacol Core Lab, New York, NY 10021 USA
[5]
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
[J].
Dondelinger, Yves
;
Declercq, Wim
;
Montessuit, Sylvie
;
Roelandt, Ria
;
Goncalves, Amanda
;
Bruggeman, Inge
;
Hulpiau, Paco
;
Weber, Kathrin
;
Sehon, Clark A.
;
Marquis, Robert W.
;
Bertin, John
;
Gough, Peter J.
;
Savvides, Savvas
;
Martinou, Jean-Claude
;
Bertrand, Mathieu J. M.
;
Vandenabeele, Peter
.
CELL REPORTS,
2014, 7 (04)
:971-981

Dondelinger, Yves
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Declercq, Wim
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Montessuit, Sylvie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Roelandt, Ria
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Goncalves, Amanda
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ghent VIB, VIB Inflammat Res Ctr, Microscopy Core Facil, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Bruggeman, Inge
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Hulpiau, Paco
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Weber, Kathrin
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Sehon, Clark A.
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Pattern Recognit Receptor Discovery Performance U, Immunoinflammat Therapeut Area, Collegeville, PA 19426 USA VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Marquis, Robert W.
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Pattern Recognit Receptor Discovery Performance U, Immunoinflammat Therapeut Area, Collegeville, PA 19426 USA VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Bertin, John
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Pattern Recognit Receptor Discovery Performance U, Immunoinflammat Therapeut Area, Collegeville, PA 19426 USA VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Gough, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Pattern Recognit Receptor Discovery Performance U, Immunoinflammat Therapeut Area, Collegeville, PA 19426 USA VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Savvides, Savvas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ghent, Lab Prot Biochem & Biomol Engn, Unit Struct Biol & Biophys, B-9000 Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Martinou, Jean-Claude
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

Bertrand, Mathieu J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
VIB Inflammat Res Ctr, B-9052 Ghent, Belgium
Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde Ghent, Belgium VIB Inflammat Res Ctr, B-9052 Ghent, Belgium

论文数: 引用数:
h-index:
机构:
[6]
Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response
[J].
Eckhardt, I.
;
Weigert, A.
;
Fulda, S.
.
CELL DEATH & DISEASE,
2014, 5
:e1562-e1562

Eckhardt, I.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

论文数: 引用数:
h-index:
机构:

Fulda, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
[7]
Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
[J].
Eckhardt, I.
;
Roesler, S.
;
Fulda, S.
.
CELL DEATH & DISEASE,
2013, 4
:e936-e936

Eckhardt, I.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Roesler, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

Fulda, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
[8]
Functional CD95 Ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
[J].
Fulda, S
;
Strauss, G
;
Meyer, E
;
Debatin, KM
.
BLOOD,
2000, 95 (01)
:301-308

Fulda, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany

Strauss, G
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany

Meyer, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany

Debatin, KM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany
[9]
Promises and Challenges of Smac Mimetics as Cancer Therapeutics
[J].
Fulda, Simone
.
CLINICAL CANCER RESEARCH,
2015, 21 (22)
:5030-5036

Fulda, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany
[10]
Therapeutic exploitation of necroptosis for cancer therapy
[J].
Fulda, Simone
.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,
2014, 35
:51-56

Fulda, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany