Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

被引：596

作者：

Xavier, B. B. ^{[1
,2
,3
]}

Lammens, C. ^{[1
,2
,3
]}

Ruhal, R. ^{[1
,2
,3
]}

Kumar-Singh, S. ^{[1
,3
,4
]}

Butaye, P. ^{[5
,6
,7
]}

Goossens, H. ^{[1
,2
,3
]}

Malhotra-Kumar, S. ^{[1
,2
,3
]}

机构：

[1] Lab Med Microbiol, Antwerp, Belgium

[2] Vaccine & Infect Dis Inst, Antwerp, Belgium

[3] Univ Antwerp, Antwerp, Belgium

[4] Mol Pathol Grp, Cell Biol & Histol, Antwerp, Belgium

[5] Univ Ghent, Fac Vet Med, Ghent, Belgium

[6] CODA CERVA, Brussels, Belgium

[7] Ross Univ, Sch Vet Med, Basseterre, St Kitts & Nevi

来源：

EUROSURVEILLANCE | 2016年 / 21卷 / 27期

关键词：

PHOSPHOETHANOLAMINE TRANSFERASE; BLA(CTX-M); SERVER;

D O I：

10.2807/1560-7917.ES.2016.21.27.30280

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

引用

页码：8 / 13

页数：6

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