Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

被引：593

作者：

Xavier, B. B. ^{[1
,2
,3
]}

Lammens, C. ^{[1
,2
,3
]}

Ruhal, R. ^{[1
,2
,3
]}

Kumar-Singh, S. ^{[1
,3
,4
]}

Butaye, P. ^{[5
,6
,7
]}

Goossens, H. ^{[1
,2
,3
]}

Malhotra-Kumar, S. ^{[1
,2
,3
]}

机构：

[1] Lab Med Microbiol, Antwerp, Belgium

[2] Vaccine & Infect Dis Inst, Antwerp, Belgium

[3] Univ Antwerp, Antwerp, Belgium

[4] Mol Pathol Grp, Cell Biol & Histol, Antwerp, Belgium

[5] Univ Ghent, Fac Vet Med, Ghent, Belgium

[6] CODA CERVA, Brussels, Belgium

[7] Ross Univ, Sch Vet Med, Basseterre, St Kitts & Nevi

来源：

EUROSURVEILLANCE | 2016年 / 21卷 / 27期

关键词：

PHOSPHOETHANOLAMINE TRANSFERASE; BLA(CTX-M); SERVER;

D O I：

10.2807/1560-7917.ES.2016.21.27.30280

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

引用

页码：8 / 13

页数：6

共 29 条

[1]

Arcilla MS, 2016, LANCET INFECT DIS, V16, P147, DOI 10.1016/S1473-3099(15)00541-1

[2] The RAST server: Rapid annotations using subsystems technology [J].

Aziz, Ramy K. ;

Bartels, Daniela ;

Best, Aaron A. ;

DeJongh, Matthew ;

Disz, Terrence ;

Edwards, Robert A. ;

Formsma, Kevin ;

Gerdes, Svetlana ;

Glass, Elizabeth M. ;

Kubal, Michael ;

Meyer, Folker ;

Olsen, Gary J. ;

Olson, Robert ;

Osterman, Andrei L. ;

Overbeek, Ross A. ;

McNeil, Leslie K. ;

Paarmann, Daniel ;

Paczian, Tobias ;

Parrello, Bruce ;

Pusch, Gordon D. ;

Reich, Claudia ;

Stevens, Rick ;

Vassieva, Olga ;

Vonstein, Veronika ;

Wilke, Andreas ;

Zagnitko, Olga .

BMC GENOMICS, 2008, 9 (1)

[3] SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing [J].

Bankevich, Anton ;

Nurk, Sergey ;

Antipov, Dmitry ;

Gurevich, Alexey A. ;

Dvorkin, Mikhail ;

Kulikov, Alexander S. ;

Lesin, Valery M. ;

Nikolenko, Sergey I. ;

Son Pham ;

Prjibelski, Andrey D. ;

Pyshkin, Alexey V. ;

Sirotkin, Alexander V. ;

Vyahhi, Nikolay ;

Tesler, Glenn ;

Alekseyev, Max A. ;

Pevzner, Pavel A. .

JOURNAL OF COMPUTATIONAL BIOLOGY, 2012, 19 (05) :455-477

[4]

Bernasconi OJ, 2016, ANTIMICROB AGENTS CH

[5] Structure of bacterial respiratory complex I [J].

Berrisford, John M. ;

Baradaran, Rozbeh ;

Sazanov, Leonid A. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2016, 1857 (07) :892-901

[6]

Conant G, GENOMEVX

[7]

EUCAST, 2016, BREAKP TABL INT MICS

[8]

Fernandes MR, 2016, EURO SURVEILL, V21, P16

[9] The Pfam protein families database: towards a more sustainable future [J].

Finn, Robert D. ;

Coggill, Penelope ;

Eberhardt, Ruth Y. ;

Eddy, Sean R. ;

Mistry, Jaina ;

Mitchell, Alex L. ;

Potter, Simon C. ;

Punta, Marco ;

Qureshi, Matloob ;

Sangrador-Vegas, Amaia ;

Salazar, Gustavo A. ;

Tate, John ;

Bateman, Alex .

NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D279-D285

[10] Impact of Plasmids, Including Those EncodingVirB4/D4 Type IV Secretion Systems, on Salmonella enterica serovar Heidelberg Virulence in Macrophages and Epithelial Cells [J].

Gokulan, Kuppan ;

Khare, Sangeeta ;

Rooney, Anthony W. ;

Han, Jing ;

Lynne, Aaron M. ;

Foley, Steven L. .

PLOS ONE, 2013, 8 (10)

← 1 2 3 →