Current Practice in Diagnosis and Treatment of Growth Hormone Deficiency in Childhood: A Survey from Turkey

被引：12

作者：

Poyrazoglu, Sukran ^{[1
]}

Akcay, Teoman ^{[2
]}

Arslanoglu, Ilknur ^{[3
]}

Atabek, Mehmet Ernie ^{[4
]}

Atay, Zeynep ^{[5
]}

Berberoglu, Merih ^{[6
]}

Bereket, Abdullah ^{[5
]}

Bideci, Aysun ^{[7
]}

Bircan, Iffet ^{[8
]}

Bober, Ece ^{[9
]}

Can, Sule ^{[10
]}

Cesur, Yasar ^{[11
]}

Darcan, Sukran ^{[12
]}

Demir, Korcan ^{[13
]}

Dundar, Bumin ^{[10
]}

Ersoy, Betul ^{[14
]}

Esen, Ihsan ^{[15
]}

Guven, Ayla ^{[16
]}

Kara, Cengiz ^{[17
]}

Keskin, Mehmet ^{[18
]}

Kurtoglu, Selim ^{[19
]}

Memioglu, Nihal ^{[20
]}

Ozbek, Mehmet Nuri ^{[21
,22
]}

Ozgen, Tolga ^{[11
]}

Sari, Erkan ^{[23
]}

Siklar, Zeynep ^{[6
]}

Simsek, Enver ^{[24
]}

Turan, Serap ^{[5
]}

Yesilkaya, Ediz ^{[23
]}

Yuksel, Bilgin ^{[25
]}

Darendeliler, Feyza ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey

[2] Bakirkoy Dr Sadi Konuk Res & Training Hosp, Clin Pediat Endocrinol, Istanbul, Turkey

[3] Duzce Univ Fac Med, Dept Pediat Endocrinol, Duzce, Turkey

[4] Necmettin Erbakan Univ Fac Med, Dept Pediat Endocrinol, Konya, Turkey

[5] Marmara Univ Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey

[6] Ankara Univ Fac Med, Dept Pediat Endocrinol, Ankara, Turkey

[7] Gazi Univ Fac Med, Dept Pediat Endocrinol, Ankara, Turkey

[8] Akdeniz Univ Fac Med, Dept Pediat Endocrinol, Antalya, Turkey

[9] Dokuz Eylul Univ Fac Med, Dept Pediat Endocrinol, Izmir, Turkey

[10] Tepecik Educ & Res Hosp, Clin Pediat Endocrinol, Izmir, Turkey

[11] Bezmialem Vakif Univ Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey

[12] Ege Univ Fac Med, Dept Pediat Endocrinol, Izmir, Turkey

[13] Dr Behcet Uz Children Dis & Surg Training & Res H, Clin Pediat Endocrinol, Izmir, Turkey

[14] Celal Bayar Univ Fac Med, Dept Pediat Endocrinol, Manisa, Turkey

[15] Firat Univ Fac Med, Dept Pediat Endocrinol, Elazig, Turkey

[16] Goztepe Educ & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey

[17] Ondokuz Mayis Univ Fac Med, Dept Pediat Endocrinol, Samsun, Turkey

[18] Gaziantep Univ Fac Med, Dept Pediat Endocrinol, Gaziantep, Turkey

[19] Erciyes Univ Fac Med, Dept Pediat Endocrinol, Kayseri, Turkey

[20] Amer Hosp, Clin Pediat Endocrinol, Istanbul, Turkey

[21] Diyarbakir Childrens State Hosp, Diyarbakir, Turkey

[22] Diyarbakir Training & Res Hosp, Diyarbakir, Turkey

[23] Gulhane Mil Med Acad, Dept Pediat Endocrinol, Ankara, Turkey

[24] Osman Gazi Univ Fac Med, Dept Pediat Endocrinol, Eskisehir, Turkey

[25] Cukurova Univ Fac Med, Dept Pediat Endocrinol, Adana, Turkey

来源：

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY | 2015年 / 7卷 / 01期

关键词：

Survey; growth hormone deficiency; childhood; PEDIATRIC ENDOCRINOLOGISTS; INSULIN TOLERANCE; PROVOCATIVE TESTS; RESEARCH SOCIETY; GH DEFICIENCY; CHILDREN; REPRODUCIBILITY; STIMULATION; GUIDELINES; VARIABILITY;

D O I：

10.4274/jcrpe.1794

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Approaches to diagnosis and treatment of growth hormone deficiency (GHD) in children vary among countries and even among centers in the same country. This survey, aiming to facilitate the process of preparing the new consensus on GHD by the Turkish Pediatric Endocrinology and Diabetes Society, was designed to evaluate the current practices in diagnosis and treatment of GHD in different centers in Turkey. Methods: A questionnaire covering relevant items for diagnosis and treatment of GHD was sent out to all pediatric endocrinology centers. Results: Twenty-four centers returned the questionnaire. The most frequently used GH stimulation test was L-dopa, followed by clonidine. Eighteen centers used a GH cut-off value of 10 ng/mL for the diagnosis of GHD; this value was 7 ng/mL in 4 centers and 5 ng/mL in 2 centers. The most frequently used assay was immunochemiluminescence for determination of GH, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 concentrations. Sex steroid priming in both sexes was used by 19 centers. The most frequently used starting dose of recombinant human GH (rhGH) in prepubertal children was 0.025-0.030 mg/kg/day and 0.030-0.035 mg/kg/day in pubertal children. Growth velocity was used in the evaluation for growth response to rhGH therapy in all centers. Anthropometric measurements of patients every 3-6 months, fasting blood glucose, bone age and thyroid panel evaluation were used by all centers at follow-up. Main indications for cessation of therapy were decreased height velocity and advanced bone age. Fourteen centers used combined treatment (rhGH and gonadotropin-releasing analogues) to increase final height. Conclusion: Although conformity was found among centers in Turkey in current practice, it is very important to update guideline statements and to modify, if needed, the approach to GHD over time in accordance with new evidence-based clinical studies.

引用

页码：37 / 44

页数：8

共 50 条

[1] European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency
Juul, A
Bernasconi, S
Clayton, PE
Kiess, W
Schrama, SDK
HORMONE RESEARCH, 2002, 58 (05) : 233 - 241
[2] Diagnosis of growth hormone deficiency in childhood
Stanley, Takara
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2012, 19 (01) : 47 - 52
[3] Diagnosis and management of growth hormone deficiency in childhood and adolescence - Part 1: Diagnosis of growth hormone deficiency
Sizonenko, PC
Clayton, PE
Cohen, P
Hintz, RL
Tanaka, T
Laron, Z
GROWTH HORMONE & IGF RESEARCH, 2001, 11 (03) : 137 - 165
[4] Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence
Murray, P. G.
Dattani, M. T.
Clayton, P. E.
ARCHIVES OF DISEASE IN CHILDHOOD, 2016, 101 (01) : 96 - 100
[5] Current concepts of the diagnosis of adult growth hormone deficiency
Tritos, Nicholas A.
Biller, Beverly M. K.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2021, 22 (01) : 109 - 116
[6] A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey
Abali, Zehra Yavas
Darendeliler, Feyza
Neyzi, Olcay
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, 2016, 8 (04) : 490 - 495
[7] Childhood growth hormone deficiency, a diagnosis in evolution: The intersection of growth hormone history and ethics
Henry, Rohan K.
GROWTH HORMONE & IGF RESEARCH, 2020, 55
[8] Diagnosis and management of growth hormone deficiency in childhood and adolescence - Part 2: Growth hormone treatment in growth hormone deficient children
Tanaka, T
Cohen, P
Clayton, PE
Laron, Z
Hintz, RL
Sizonenko, PC
GROWTH HORMONE & IGF RESEARCH, 2002, 12 (05) : 323 - 341
[9] Diagnosis of childhood and adolescent growth hormone deficiency using transcriptomic data
Garner, Terence
Wangsaputra, Ivan
Whatmore, Andrew
Clayton, Peter Ellis
Stevens, Adam
Murray, Philip George
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[10] Discontinuation of long-term growth hormone treatment in adults with growth hormone deficiency: a survey of UK practice
Criseno, Sherwin
Gleeson, Helena
Toogood, Andrew A.
Gittoes, Neil
Topping, Anne
Karavitaki, Niki
ENDOCRINE CONNECTIONS, 2024, 13 (05)

← 1 2 3 4 5 →