Molecular structure and pseudopolymorphism of squamtin A from Annona squamosa

被引：13

作者：

Jiang, RW

Lu, Y

Min, ZD

Zheng, QT

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] China Pharmaceut Univ, Dept Nat Pharmaceut Chem, Nanjing, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2003年 / 655卷 / 01期

基金：

中国国家自然科学基金;

关键词：

squamin A; cyclopeptide; pseudopolymorphism; Annona squamosa;

D O I：

10.1016/S0022-2860(03)00227-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The cyclopeptide, squamtin A (1, formula: C39H60O11N8S), was found to crystallized in two pseudopolymorphisms, i.e. 1.(H2O)(3.5) and 1.(H2O)(3.9). The composition of the amino acids and their linkage sequences are the same. The main differences between the two kinds of crystals lie in the positions and occupancies of the water molecules, the positions of the sulfur atoms and the conformation of the side chains. The absolute configuration of 1 is established by X-ray analysis in combination with the Marfey's analysis of its hydrolysates. (C) 2003 Elsevier Science B.V. All rights reserved.

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页码：157 / 162

页数：6

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