Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

被引：46
|
作者：
Garg, Divita [1 ,2 ]
Henrich, Stefan [1 ]
Salo-Ahen, Outi M. H. [1 ,3 ]
Myllykallio, Hannu [4 ]
Costi, Maria P. [5 ]
Wade, Rebecca C. [1 ]
机构：
[1] Heidelberg Inst Theoret Studies gGmbH, Mol & Cellular Modeling Grp, Heidelberg, Germany
[2] Helmholtz Zentrum Munchen, Inst Biol Struct, Neuherberg, Germany
[3] Abo Akad Univ, Dept Biosci, Turku, Finland
[4] Ecole Polytech, CNRS, INSERM, Lab Opt & Biosci,UMR7645,U696, F-91128 Palaiseau, France
[5] Univ Modena & Reggio Emilia, Dipartimento Sci Farmaceut, Modena, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 18期
关键词：
HISTONE DEACETYLASE INHIBITOR; ENHANCES 5-FLUOROURACIL CYTOTOXICITY; MESSENGER-RNA TRANSLATION; GENE-EXPRESSION; CELL-GROWTH; DIHYDROFOLATE-REDUCTASE; ANTITUMOR-ACTIVITY; DOWN-REGULATION; HUMAN LIVER; IN-VITRO;
D O I：
10.1021/jm901869w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：6539 / 6549
页数：11
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