Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

被引：46
|
作者：
Garg, Divita [1 ,2 ]
Henrich, Stefan [1 ]
Salo-Ahen, Outi M. H. [1 ,3 ]
Myllykallio, Hannu [4 ]
Costi, Maria P. [5 ]
Wade, Rebecca C. [1 ]
机构：
[1] Heidelberg Inst Theoret Studies gGmbH, Mol & Cellular Modeling Grp, Heidelberg, Germany
[2] Helmholtz Zentrum Munchen, Inst Biol Struct, Neuherberg, Germany
[3] Abo Akad Univ, Dept Biosci, Turku, Finland
[4] Ecole Polytech, CNRS, INSERM, Lab Opt & Biosci,UMR7645,U696, F-91128 Palaiseau, France
[5] Univ Modena & Reggio Emilia, Dipartimento Sci Farmaceut, Modena, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 18期
关键词：
HISTONE DEACETYLASE INHIBITOR; ENHANCES 5-FLUOROURACIL CYTOTOXICITY; MESSENGER-RNA TRANSLATION; GENE-EXPRESSION; CELL-GROWTH; DIHYDROFOLATE-REDUCTASE; ANTITUMOR-ACTIVITY; DOWN-REGULATION; HUMAN LIVER; IN-VITRO;
D O I：
10.1021/jm901869w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：6539 / 6549
页数：11
相关论文
共 50 条
  • [21] Targeting Thymidylate Synthase mRNA regulatory element with a novel family of Berberine derivatives
    Plasencia, C.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S94 - S94
  • [22] Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells
    Zhou, Ting
    Duan, Jingjing
    Wang, Yan
    Chen, Xin
    Zhou, Ganping
    Wang, Rongkan
    Fu, Liwu
    Xu, Feng
    TUMOR BIOLOGY, 2012, 33 (05) : 1299 - 1306
  • [23] Fighting tubulin-targeting anticancer drug toxicity and resistance
    Visconti, Roberta
    Grieco, Domenico
    ENDOCRINE-RELATED CANCER, 2017, 24 (09) : T107 - T117
  • [24] New Triazole Hybrids as Anticancer Agents Targeting Thymidylate Synthase: Synthesis, Biological and Molecular Docking Studies
    Alam, Mohammad Mahboob
    Alsenani, Nawaf I.
    Elbehairi, Serag Eldin I.
    Nazreen, Syed
    Amairia, Chahra
    Alfarsi, Anas
    Hussien, Rania A.
    Asad, Mohammad
    Alzahrani, Khalid Ahmed
    Shati, Ali A.
    Alfaifi, Mohammad Y.
    Elhenawy, Ahmed A.
    POLYCYCLIC AROMATIC COMPOUNDS, 2025,
  • [25] Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance
    Souchek, Joshua J.
    Muraskin, Lindsey
    Houser, Lucas
    Quyen Vu
    Mohs, Aaron M.
    VISUALIZING AND QUANTIFYING DRUG DISTRIBUTION IN TISSUE III, 2019, 10859
  • [26] Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance
    Takemura, Y
    Kobayashi, H
    Miyachi, H
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 1997, 66 (04) : 459 - 477
  • [27] Primary cilia: a novel research approach to overcome anticancer drug resistance
    Lee, Kyung Ho
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 10
  • [28] Novel Nrf2 inhibitors and their application to overcome chemoresistance of anticancer drugs
    Kumar, Vineet
    Foygel, Kira
    Paulmurugan, Ramasamy
    Malhotra, Sanjay V.
    CANCER RESEARCH, 2016, 76
  • [29] Angiogenesis and Pancreatic Cancer: Novel Approaches to Overcome Treatment Resistance
    Grobbelaar, Craig
    Kgomo, Mpho
    Mabeta, Peace
    CURRENT CANCER DRUG TARGETS, 2024, 24 (11) : 1116 - 1127
  • [30] Combining siRNAs Targeting Thymidylate Synthase and Thymidine Kinase 1 or 2 Sensitizes Human Tumor Cells to the Anticancer Drugs 5FUdR, Pemetrexed and Gemcitabine
    Di Cresce, C.
    Figueredo, R.
    Ferguson, P. J.
    Vincent, M. D.
    Koropatnick, J.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : 58 - 58
12345