The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

被引：1

作者：

Kim, So Young ^{[1
]}

Yoo, Dae Myoung ^{[2
]}

Kwon, Mi Jung ^{[3
]}

Kim, Ji Hee ^{[4
]}

Kim, Joo-Hee ^{[5
]}

Bang, Woo Jin ^{[6
]}

Kim, Sung Kyun ^{[7
]}

Choi, Hyo Geun ^{[1
,7
]}

机构：

[1] CHA Univ, Bundang CHA Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam 13488, South Korea

[2] Hallym Univ, Coll Med, Hallym Data Sci Lab, Anyang 14068, South Korea

[3] Hallym Univ, Hallym Sacred Heart Hosp, Coll Med, Dept Pathol, Anyang 14068, South Korea

[4] Hallym Univ, Coll Med, Dept Neurosurg, Anyang 14068, South Korea

[5] Hallym Univ, Hallym Sacred Heart Hosp, Coll Med, Div Pulm Allergy & Crit Care Med,Dept Med, Anyang 14068, South Korea

[6] Hallym Univ, Hallym Sacred Heart Hosp, Coll Med, Dept Urol, Anyang 14068, South Korea

[7] Hallym Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Anyang 14068, South Korea

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

gout; thyroid cancer; risk factors; cohort studies; epidemiology; RISK-FACTORS; DISORDERS;

D O I：

10.3390/jpm12060887

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In this study, we investigated the risk of thyroid cancer in patients with gout. Participants >= 40 years old in the Korean National Health Insurance Service-Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case-control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the <60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.

引用

页数：9

共 21 条

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