A role for carbohydrates in immune evasion in AIDS

被引：493

作者：

Reitter, JN ^{[1
]}

Means, RE ^{[1
]}

Desrosiers, RC ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Southborough, MA 01772 USA

来源：

NATURE MEDICINE | 1998年 / 4卷 / 06期

关键词：

D O I：

10.1038/nm0698-679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhesus monkeys were infected with mutant forms of simian immunodeficiency virus lacking dual combinations of the 4th, 5th and 6th sites for N-linked glycosylation in the external envelope glycoprotein of the virus. When compared with sera from monkeys infected with the parental virus, sera from monkeys infected with the mutant viruses exhibited markedly increased antibody binding to specific peptides from this region and markedly increased neutralizing activity. These results demonstrate a role for N-linked glycosylation in limiting the neutralizing antibody response to SIV and in shielding the virus from immune recognition.

引用

页码：679 / 684

页数：6

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