Synthesis of isogranulatimides A and B analogues possessing a 7-azaindole unit instead of an indole moiety

被引：25
作者：
Hugon, B
Pfeiffer, B
Renard, P
Prudhomme, M [1 ]
机构：
[1] Univ Clermont Ferrand, CNRS, Synth & Etud Syst Interet Biol UMR 6504, F-63177 Clermont Ferrand, France
[2] Les Labs SERVIER, F-92415 Courbevoie, France
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期
关键词：
G2 checkpoint inhibitors; isogranulatimide; rebeccamycin;
D O I：
10.1016/S0040-4039(03)00924-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a new family of isogranulatimides analogues is described in which a 7-azaindole replaces the indole moiety. The key step is the photocyclization of the aza didemnimide intermediates which leads to two isomeric analogues of isogranulatimides A and B. A derivative bearing a carbohydrate part linked to the azaindole via a beta-N-glycosidic bond was also prepared. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：4607 / 4611
页数：5
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