The rabbit as a model for reproductive and developmental toxicity studies

被引:92
作者
Foote, RH
Carney, EW
机构
[1] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA
[2] Dow Chem Co USA, Dev & Reprod Toxicol, Midland, MI 48674 USA
关键词
rabbit model; reproductive physiology; fertility assessment; development toxicity; teratology;
D O I
10.1016/S0890-6238(00)00101-5
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The rabbit has many advantages as a nonrodent and second model for assessing the effects of toxic agents on semen quality, fertility, developmental toxicity, and teratology. The male and female reproductive systems of the rabbit are described, and data on growth, sexual development and reproduction are compared with mice, rats, and humans. Techniques for semen collection and evaluation in the male, and artificial insemination, superovulation, embryo culture, and embryo transfer in the female are included as useful procedures in toxicity testing. Examples of the use of rabbits and experimental replication for toxicity testing are given. Special features of the visceral yolk sac and development of the chorioallantoic placenta of the rabbit are compared with rodents. The rabbit extraembryonic membranes more closely resemble the human than do the rodents, in some respects. The use of the rabbit in developmental toxicity and teratology studies is discussed. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:477 / 493
页数:17
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