Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives

被引：15

作者：

Lu, Haibin ^{[1
]}

Kong, Dejuan ^{[1
]}

Wu, Bin ^{[1
]}

Wang, Shihan ^{[2
]}

Wang, Yongsheng ^{[1
]}

机构：

[1] Jilin Univ, Coll Pharm, Changchun 130021, Peoples R China

[2] Liaoning Univ Tradit Chinese Med, Shenyang 116600, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 06期

关键词：

Anti-inflammatory activity; Antitussive activity; Biological activity; Hydantoin; Ibuprofen; Synthesis;

D O I：

10.2174/157018012800673092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.

引用

页码：638 / 642

页数：5

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