Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats

被引：11
作者：
Nielsen, DM [1 ]
Crosley, KJ [1 ]
Keller, RW [1 ]
Glick, SD [1 ]
Carlson, JN [1 ]
机构：
[1] Albany Med Coll, Dept Pharmacol & Neurosci, Albany, NY 12208 USA
来源：
BRAIN RESEARCH | 1999年 / 823卷 / 1-2期
关键词：
medial prefrontal cortex; brain asymmetry; dopamine; locomotor activity behavior; ethanol; nucleus accumbens;
D O I：
10.1016/S0006-8993(99)01129-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ethanol(0.5 g/kg i.p.) 15 min prior to sacrifice increased homovanillic acid (HVA) levels in the left medial prefrontal cortex (mPFC) of left-turning rats and in the right mPFC of right-turning rats. In the nucleus accumbens (NAS), ethanol decreased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and HVA levels in rats that exhibited low levels of locomotor activity but not in rats that exhibited high levels of locomotor activity. This laboratory has previously shown that rats exhibiting differences in turning and locomotor activity behavior display different preferences for ethanol. The present results suggest that ethanol-induced differences in mPFC and NAS DA activity may be related to individual differences in the susceptibility to abuse ethanol. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：207 / 212
页数：6
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