Optical Resonator Biosensors: Molecular Diagnostic and Nanoparticle Detection on an Integrated Platform

被引:99
作者
Baaske, Martin [1 ]
Vollmer, Frank [1 ]
机构
[1] Max Planck Inst Sci Light, Lab Biophoton & Biosensing, D-91058 Erlangen, Germany
关键词
label-free biosensing; lab-on-a-chip; microfluidic integration; nanoparticle detection; optical resonator; WHISPERING-GALLERY MODES; LABEL-FREE DETECTION; MICRORING-RESONATOR; SINGLE MOLECULES; SHIFT; MANIPULATION; LITHOGRAPHY; FABRICATION; SENSORS;
D O I
10.1002/cphc.201100757
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Optical resonator biosensors are emerging as one of the most sensitive microsystem biodetection technology that does not require amplification or labeling of the analyte. This minireview provides a scholarly introduction to this research area and reviews current advances in molecular diagnostics and nanoparticle detection.
引用
收藏
页码:427 / 436
页数:10
相关论文
共 69 条
[1]   Label-free, single-molecule detection with optical microcavities [J].
Armani, Andrea M. ;
Kulkarni, Rajan P. ;
Fraser, Scott E. ;
Flagan, Richard C. ;
Vahala, Kerry J. .
SCIENCE, 2007, 317 (5839) :783-787
[2]   Shift of whispering-gallery modes in microspheres by protein adsorption [J].
Arnold, S ;
Khoshsima, M ;
Teraoka, I ;
Holler, S ;
Vollmer, F .
OPTICS LETTERS, 2003, 28 (04) :272-274
[3]   Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism [J].
Arnold, S. ;
Shopova, S. I. ;
Holler, S. .
OPTICS EXPRESS, 2010, 18 (01) :281-287
[4]   Whispering gallery mode carousel - a photonic mechanism for enhanced nanoparticle detection in biosensing [J].
Arnold, S. ;
Keng, D. ;
Shopova, S. I. ;
Holler, S. ;
Zurawsky, W. ;
Vollmer, F. .
OPTICS EXPRESS, 2009, 17 (08) :6230-6238
[5]   Self-referenced photonic molecule bio(chemical)sensor [J].
Boriskina, Svetlana V. ;
Dal Negro, Luca .
OPTICS LETTERS, 2010, 35 (14) :2496-2498
[6]   Optical manipulation and transport of microparticles on silicon nitride microring-resonator-based add-drop devices [J].
Cai, Hong ;
Poon, Andrew W. .
OPTICS LETTERS, 2010, 35 (17) :2855-2857
[7]   Biochemical sensors based on polymer microrings with sharp asymmetrical resonance [J].
Chao, CY ;
Guo, LJ .
APPLIED PHYSICS LETTERS, 2003, 83 (08) :1527-1529
[8]   Silicon-on-Insulator microring resonator for sensitive and label-free biosensing [J].
De Vos, Katrien ;
Bartolozzi, Irene ;
Schacht, Etienne ;
Bienstman, Peter ;
Baets, Roel .
OPTICS EXPRESS, 2007, 15 (12) :7610-7615
[9]   Whispering gallery microresonators for second harmonic light generation from a low number of small molecules [J].
Dominguez-Juarez, J. L. ;
Kozyreff, G. ;
Martorell, Jordi .
NATURE COMMUNICATIONS, 2011, 2
[10]   Fabrication of high-Q polydimethylsiloxane optical microspheres for thermal sensing [J].
Dong, C. -H. ;
He, L. ;
Xiao, Y. -F. ;
Gaddam, V. R. ;
Ozdemir, S. K. ;
Han, Z. -F. ;
Guo, G. -C. ;
Yang, L. .
APPLIED PHYSICS LETTERS, 2009, 94 (23)