The role of PI 3-kinase in insulin action

被引：172
作者：
Alessi, DR [1 ]
Downes, CP [1 ]
机构：
[1] Univ Dundee, Dept Biochem, Dundee DD1 5EH, Scotland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1998年 / 1436卷 / 1-2期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
PI; 3-kinase; protein kinase B; insulin action;
D O I：
10.1016/S0005-2760(98)00133-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review focuses on the recent advances made in our understanding of the mechanism by which insulin induces the activation of PI 3-kinase(s) whose role is to generate 3-phosphoinositide lipids which are the second messenger of the insulin signalling pathway. The mechanism by which these signalling molecules induce the activation of downstream signalling pathways leading to the activation of protein kinase B (PKB, also known as Akt) and other kinases is also discussed. PKB is likely to be a major mediator of many of the physiological responses of a cell to insulin and likely physiological cellular targets of this enzyme are highlighted. (C) 1998 Elsevier Science B,V, All rights reserved.
引用
收藏
页码：151 / 164
页数：14
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