Functionalized Flexible Soft Polymer Optical Fibers for Laser Photomedicine

Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long-term implantation has been limited with solid-state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step-index core/cladded poly(acrylamide-co-poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free-radical polymerization in a mold. The SPOF is integrated with a solid-state silica fiber coupler for efficient light delivery. The cladded SPOF shows approximate to 1.5-fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm(-1) at the bending angle of 70 degrees and 0.28 dB cm(-1) through a phantom tissue. The SPOF (inner empty set = 200 mu m) integrated with a 21 gauge needle (inner empty set = 514 mu m) is inserted within a porcine tissue. The intensity of light decreases approximate to 60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow-red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.